Aminopropyl thiophene compounds

Goodman, Mark M

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Title: Aminopropyl thiophene compounds

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Abstract

Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation of regional blood flow by radioimaging of the brain.

Inventors:

Goodman, Mark M ^[1]; Knapp, Jr., Furn F. ^[2]

Knoxville, TN
(Oak Ridge, TN)

Issue Date:: Mon Jan 01 00:00:00 EST 1990

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 867325

Patent Number(s):: 4914215

Assignee:: United States of America as represented by United States (Washington, DC)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2123/00 - Preparations for testing in vivo
A61K51/0431 - {having five-membered rings}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F5/025 - {Boronic and borinic acid compounds}
C07F7/2208 - {Compounds having tin linked only to carbon, hydrogen and/or halogen}

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Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: aminopropyl; thiophene; compounds; radiopharmaceuticals; useful; brain; imaging; comprising; radiohalogenated; thienylethylamine; derivatives; 5-halo-thiophene-2-isopropyl; amines; blood-brain; barrier; retained; sufficient; length; time; allow; evaluation; regional; blood; flow; radioimaging; blood flow; sufficient length; radiohalogenated thienylethylamine; thienylethylamine derivatives; radiopharmaceuticals useful; comprising radiohalogenated; imaging comprising; brain imaging; blood-brain barrier; /999/

Citation Formats


                    Goodman, Mark M, and Knapp, Jr., Furn F. Aminopropyl thiophene compounds.  United States: N. p., 1990. 
        Web.

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                    Goodman, Mark M, & Knapp, Jr., Furn F. Aminopropyl thiophene compounds.  United States.

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                    Goodman, Mark M, and Knapp, Jr., Furn F. Mon .  
        "Aminopropyl thiophene compounds".  United States.  https://www.osti.gov/servlets/purl/867325.

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@article{osti_867325,

  title        = {Aminopropyl thiophene compounds},

  author       = {Goodman, Mark M and Knapp, Jr., Furn F.},

  abstractNote = {Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation of regional blood flow by radioimaging of the brain.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Mon Jan 01 00:00:00 EST 1990},

  month        = {Mon Jan 01 00:00:00 EST 1990}

}

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