Biological particle identification apparatus
Abstract
An apparatus and method for making multiparameter light scattering measurements from suspensions of biological particles is described. Fourteen of the sixteen Mueller matrix elements describing the particles under investigation can be substantially individually determined as a function of scattering angle and probing radiations wavelength, eight elements simultaneously for each of two apparatus configurations using an apparatus which incluees, in its simplest form, two polarization modulators each operating at a chosen frequency, one polarizer, a source of monochromatic electromagnetic radiation, a detector sensitive to the wavelength of radiation employed, eight phase-sensitive detectors, and appropriate electronics. A database of known biological particle suspensions can be assembled, and unknown samples can be quickly identified once measurements are performed on it according to the teachings of the subject invention, and a comparison is made with the database.
- Inventors:
-
- Los Alamos, NM
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- OSTI Identifier:
- 867196
- Patent Number(s):
- 4884886
- Assignee:
- United States of America as represented by Department of Energy (Washington, DC)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- biological; particle; identification; apparatus; method; multiparameter; light; scattering; measurements; suspensions; particles; described; fourteen; sixteen; mueller; matrix; elements; describing; investigation; substantially; individually; determined; function; angle; probing; radiations; wavelength; eight; simultaneously; configurations; incluees; simplest; form; polarization; modulators; operating; chosen; frequency; polarizer; source; monochromatic; electromagnetic; radiation; detector; sensitive; employed; phase-sensitive; detectors; appropriate; electronics; database; assembled; samples; quickly; identified; performed; according; teachings; subject; comparison; mueller matrix; biological particle; light scattering; electromagnetic radiation; sensitive detector; biological particles; particle suspension; scattering angle; appropriate electronics; scattering measurements; monochromatic electromagnetic; particle suspensions; particle identification; simplest form; polarization modulator; matrix elements; /356/250/
Citation Formats
Salzman, Gary C, Gregg, Charles T, Grace, W Kevin, and Hiebert, Richard D. Biological particle identification apparatus. United States: N. p., 1989.
Web.
Salzman, Gary C, Gregg, Charles T, Grace, W Kevin, & Hiebert, Richard D. Biological particle identification apparatus. United States.
Salzman, Gary C, Gregg, Charles T, Grace, W Kevin, and Hiebert, Richard D. Sun .
"Biological particle identification apparatus". United States. https://www.osti.gov/servlets/purl/867196.
@article{osti_867196,
title = {Biological particle identification apparatus},
author = {Salzman, Gary C and Gregg, Charles T and Grace, W Kevin and Hiebert, Richard D},
abstractNote = {An apparatus and method for making multiparameter light scattering measurements from suspensions of biological particles is described. Fourteen of the sixteen Mueller matrix elements describing the particles under investigation can be substantially individually determined as a function of scattering angle and probing radiations wavelength, eight elements simultaneously for each of two apparatus configurations using an apparatus which incluees, in its simplest form, two polarization modulators each operating at a chosen frequency, one polarizer, a source of monochromatic electromagnetic radiation, a detector sensitive to the wavelength of radiation employed, eight phase-sensitive detectors, and appropriate electronics. A database of known biological particle suspensions can be assembled, and unknown samples can be quickly identified once measurements are performed on it according to the teachings of the subject invention, and a comparison is made with the database.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}