Generator for ionic gallium-68 based on column chromatography

Neirinckx, Rudi D; Davis, Michael A

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Title: Generator for ionic gallium-68 based on column chromatography

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Abstract

A physiologically acceptable solution of gallium-68 fluorides, having an activity of 0.1 to 50 millicuries per milliliter of solution is provided. The solution is obtained from a generator comprising germanium-68 hexafluoride bound to a column of an anion exchange resin which forms gallium-68 in situ by eluting the column with an acid solution to form a solution containing .sup.68 Ga-fluorides. The solution then is neutralized prior to administration.

Inventors:

Neirinckx, Rudi D ^[1]; Davis, Michael A ^[2]

Medfield, MA
Westwood, MA

Issue Date:: Thu Jan 01 00:00:00 EST 1981

OSTI Identifier:: 863980

Patent Number(s):: 4288424

Assignee:: Massachusetts Institute of Technology (Cambridge, MA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2123/00 - Preparations for testing in vivo
A61K51/02 - characterised by the carrier {, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus}
A61K51/1282 - {Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents}

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G1/04 - outside nuclear reactors or particle accelerators

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DOE Contract Number:: E(11-1)-4115

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: generator; ionic; gallium-68; based; column; chromatography; physiologically; acceptable; solution; fluorides; activity; 50; millicuries; milliliter; provided; obtained; comprising; germanium-68; hexafluoride; bound; anion; exchange; resin; forms; situ; eluting; acid; form; containing; 68; ga-fluorides; neutralized; prior; administration; anion exchange; acid solution; solution containing; exchange resin; acceptable solution; column chromatography; physiologically acceptable; generator comprising; /424/250/376/422/521/976/

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                    Neirinckx, Rudi D, and Davis, Michael A. Generator for ionic gallium-68 based on column chromatography.  United States: N. p., 1981. 
        Web.

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                    Neirinckx, Rudi D, & Davis, Michael A. Generator for ionic gallium-68 based on column chromatography.  United States.

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                    Neirinckx, Rudi D, and Davis, Michael A. Thu .  
        "Generator for ionic gallium-68 based on column chromatography".  United States.  https://www.osti.gov/servlets/purl/863980.

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@article{osti_863980,

  title        = {Generator for ionic gallium-68 based on column chromatography},

  author       = {Neirinckx, Rudi D and Davis, Michael A},

  abstractNote = {A physiologically acceptable solution of gallium-68 fluorides, having an activity of 0.1 to 50 millicuries per milliliter of solution is provided. The solution is obtained from a generator comprising germanium-68 hexafluoride bound to a column of an anion exchange resin which forms gallium-68 in situ by eluting the column with an acid solution to form a solution containing .sup.68 Ga-fluorides. The solution then is neutralized prior to administration.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Thu Jan 01 00:00:00 EST 1981},

  month        = {Thu Jan 01 00:00:00 EST 1981}

}

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