Method for microbeam radiation therapy
Abstract
A method is disclosed of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation. The dose is in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue. No Drawings
- Inventors:
- Issue Date:
- OSTI Identifier:
- 7159544
- Patent Number(s):
- 5339347
- Application Number:
- PPN: US 8-052927
- Assignee:
- Dept. of Energy, Washington, DC (United States)
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 27 Apr 1993
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; ANIMAL TISSUES; RADIATION DOSES; NEOPLASMS; RADIOTHERAPY; OPTIMIZATION; BODY; DISEASES; DOSES; MEDICINE; NUCLEAR MEDICINE; RADIOLOGY; THERAPY; TISSUES; 550603* - Medicine- External Radiation in Therapy- (1980-)
Citation Formats
Slatkin, D N, Dilmanian, F A, and Spanne, P O. Method for microbeam radiation therapy. United States: N. p., 1994.
Web.
Slatkin, D N, Dilmanian, F A, & Spanne, P O. Method for microbeam radiation therapy. United States.
Slatkin, D N, Dilmanian, F A, and Spanne, P O. Tue .
"Method for microbeam radiation therapy". United States.
@article{osti_7159544,
title = {Method for microbeam radiation therapy},
author = {Slatkin, D N and Dilmanian, F A and Spanne, P O},
abstractNote = {A method is disclosed of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation. The dose is in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue. No Drawings},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 16 00:00:00 EDT 1994},
month = {Tue Aug 16 00:00:00 EDT 1994}
}