Freeze chromatography method and apparatus
Abstract
A freeze chromatography method and apparatus are provided which enable separation of the solutes contained in a sample. The apparatus includes an annular column construction comprising cylindrical inner and outer surfaces defining an annular passage therebetween. One of the surfaces is heated and the other cooled while passing an eluent through the annular passageway so that the eluent in contact with the cooled surface freezes and forms a frozen eluent layer thereon. A mixture of solutes dissolved in eluent is passed through the annular passageway in contact with the frozen layer so that the sample solutes in the mixture will tend to migrate either toward or away the frozen layer. The rate at which the mixture flows through the annular passageway is controlled so that the distribution of the sample solutes approaches that at equilibrium and thus a separation between the sample solutes occurs. 3 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 7045071
- Patent Number(s):
- 6039130
- Assignee:
- TIC; EDB-88-178525
- Patent Classifications (CPCs):
-
E - FIXED CONSTRUCTIONS E21 - EARTH DRILLING E21B - EARTH DRILLING, e.g. DEEP DRILLING
- DOE Contract Number:
- AC05-84OR21400
- Resource Type:
- Patent
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CHROMATOGRAPHY; INVENTIONS; EXTRACTION COLUMNS; FREEZING; DESIGN; ELUTRIATION; MIXTURES; SOLUTES; SURFACES; DISPERSIONS; EXTRACTION APPARATUSES; SEPARATION EQUIPMENT; SEPARATION PROCESSES; 400102* - Chemical & Spectral Procedures
Citation Formats
Scott, C D. Freeze chromatography method and apparatus. United States: N. p., 1987.
Web.
Scott, C D. Freeze chromatography method and apparatus. United States.
Scott, C D. Thu .
"Freeze chromatography method and apparatus". United States.
@article{osti_7045071,
title = {Freeze chromatography method and apparatus},
author = {Scott, C D},
abstractNote = {A freeze chromatography method and apparatus are provided which enable separation of the solutes contained in a sample. The apparatus includes an annular column construction comprising cylindrical inner and outer surfaces defining an annular passage therebetween. One of the surfaces is heated and the other cooled while passing an eluent through the annular passageway so that the eluent in contact with the cooled surface freezes and forms a frozen eluent layer thereon. A mixture of solutes dissolved in eluent is passed through the annular passageway in contact with the frozen layer so that the sample solutes in the mixture will tend to migrate either toward or away the frozen layer. The rate at which the mixture flows through the annular passageway is controlled so that the distribution of the sample solutes approaches that at equilibrium and thus a separation between the sample solutes occurs. 3 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Apr 16 00:00:00 EDT 1987},
month = {Thu Apr 16 00:00:00 EDT 1987}
}