Optical reaction cell and light source for [18F] fluoride radiotracer synthesis
Abstract
An apparatus is disclosed for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-[{sup 18}F]fluoro-2-deoxy-Dglucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of [{sup 18}F]-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-[{sup 18}F]fluoro-2-deoxy-D-glucose in higher yields than previously possible. 4 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Associated Universities Inc
- Sponsoring Org.:
- USDOE, Washington, DC (United States)
- OSTI Identifier:
- 672679
- Patent Number(s):
- 5808020
- Application Number:
- PAN: 8-694,398; TRN: 99:001109
- Assignee:
- Associated Universities, Inc., Washington, DC (United States)
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 15 Sep 1998
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; FLUORINE 18
Citation Formats
Ferrieri, R A, Schlyer, D, and Becker, R J. Optical reaction cell and light source for [18F] fluoride radiotracer synthesis. United States: N. p., 1998.
Web.
Ferrieri, R A, Schlyer, D, & Becker, R J. Optical reaction cell and light source for [18F] fluoride radiotracer synthesis. United States.
Ferrieri, R A, Schlyer, D, and Becker, R J. Tue .
"Optical reaction cell and light source for [18F] fluoride radiotracer synthesis". United States.
@article{osti_672679,
title = {Optical reaction cell and light source for [18F] fluoride radiotracer synthesis},
author = {Ferrieri, R A and Schlyer, D and Becker, R J},
abstractNote = {An apparatus is disclosed for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-[{sup 18}F]fluoro-2-deoxy-Dglucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of [{sup 18}F]-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-[{sup 18}F]fluoro-2-deoxy-D-glucose in higher yields than previously possible. 4 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 15 00:00:00 EDT 1998},
month = {Tue Sep 15 00:00:00 EDT 1998}
}