Process for the separation and purification of yttrium-90 for medical applications
Abstract
An extraction chromatographic method for the preparation of [sup 90]Y of high chemical and radiochemical purity is disclosed. After an initial purification of a [sup 90]Sr stock solution and a suitable period of [sup 90]Y ingrowth, the solution is passed through a series of strontium-selective chromatographic columns, each of which lowers the [sup 90]Sr content of the mixture by a factor of about 10[sup 3]. The [sup 90]Y remaining is freed from any residual [sup 90]Sr, from its [sup 90]Zr daughter, and from any remaining impurities by passing the sample through a final column designed to selectively retain yttrium. 5 figures.
- Inventors:
- Issue Date:
- OSTI Identifier:
- 6649133
- Patent Number(s):
- 5368736
- Application Number:
- PPN: US 8-095555
- Assignee:
- Dept. of Energy, Washington, DC (United States)
- DOE Contract Number:
- W-31109-ENG-38
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 26 Jul 1993
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; YTTRIUM 90; CHROMATOGRAPHY; PURIFICATION; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; SEPARATION PROCESSES; SYNTHESIS; YTTRIUM ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 400105 - Separation Procedures
Citation Formats
Horwitz, P E, and Dietz, M L. Process for the separation and purification of yttrium-90 for medical applications. United States: N. p., 1994.
Web.
Horwitz, P E, & Dietz, M L. Process for the separation and purification of yttrium-90 for medical applications. United States.
Horwitz, P E, and Dietz, M L. Tue .
"Process for the separation and purification of yttrium-90 for medical applications". United States.
@article{osti_6649133,
title = {Process for the separation and purification of yttrium-90 for medical applications},
author = {Horwitz, P E and Dietz, M L},
abstractNote = {An extraction chromatographic method for the preparation of [sup 90]Y of high chemical and radiochemical purity is disclosed. After an initial purification of a [sup 90]Sr stock solution and a suitable period of [sup 90]Y ingrowth, the solution is passed through a series of strontium-selective chromatographic columns, each of which lowers the [sup 90]Sr content of the mixture by a factor of about 10[sup 3]. The [sup 90]Y remaining is freed from any residual [sup 90]Sr, from its [sup 90]Zr daughter, and from any remaining impurities by passing the sample through a final column designed to selectively retain yttrium. 5 figures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 29 00:00:00 EST 1994},
month = {Tue Nov 29 00:00:00 EST 1994}
}
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