Modified acyl-ACP desaturase
Abstract
Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity. 1 fig.
- Inventors:
- Issue Date:
- Research Org.:
- Associated Universities Inc
- Sponsoring Org.:
- USDOE, Washington, DC (United States)
- OSTI Identifier:
- 563670
- Patent Number(s):
- 5705391
- Application Number:
- PAN: 8-689,823
- Assignee:
- Associated Universities, Inc., Washington, DC (United States)
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 6 Jan 1998
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; OXYGENASES; SPECIFICITY; BIOCHEMICAL REACTION KINETICS; ENZYME ACTIVITY; CHEMICAL BONDS; CARBOXYLIC ACIDS
Citation Formats
Cahoon, E B, Shanklin, J, Lindgvist, Y, and Schneider, G. Modified acyl-ACP desaturase. United States: N. p., 1998.
Web.
Cahoon, E B, Shanklin, J, Lindgvist, Y, & Schneider, G. Modified acyl-ACP desaturase. United States.
Cahoon, E B, Shanklin, J, Lindgvist, Y, and Schneider, G. Tue .
"Modified acyl-ACP desaturase". United States.
@article{osti_563670,
title = {Modified acyl-ACP desaturase},
author = {Cahoon, E B and Shanklin, J and Lindgvist, Y and Schneider, G},
abstractNote = {Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity. 1 fig.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 06 00:00:00 EST 1998},
month = {Tue Jan 06 00:00:00 EST 1998}
}
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