Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy
Abstract
A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.
- Inventors:
- Issue Date:
- Research Org.:
- Associated Universities Inc
- Sponsoring Org.:
- USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
- OSTI Identifier:
- 516929
- Patent Number(s):
- 5653957
- Application Number:
- PAN: 8-740,693; CNN: Grant IR01CA38107-01A2; TRN: 97:014586
- Assignee:
- Associated Universities, Inc., Washington, DC (United States)
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 5 Aug 1997
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; RADIOPHARMACEUTICALS; NEUTRON CAPTURE THERAPY; BORON 10; CHEMICAL PREPARATION; NEOPLASMS; LET
Citation Formats
Miura, M, and Slatkin, D N. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy. United States: N. p., 1997.
Web.
Miura, M, & Slatkin, D N. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy. United States.
Miura, M, and Slatkin, D N. Tue .
"Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy". United States.
@article{osti_516929,
title = {Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy},
author = {Miura, M and Slatkin, D N},
abstractNote = {A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 05 00:00:00 EDT 1997},
month = {Tue Aug 05 00:00:00 EDT 1997}
}