Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells
Abstract
An apparatus and method are disclosed for microscopic and spectroscopic analysis and processing of biological cells. The apparatus comprises a laser having an analysis region within the laser cavity for containing one or more biological cells to be analyzed. The presence of a cell within the analysis region in superposition with an activated portion of a gain medium of the laser acts to encode information about the cell upon the laser beam, the cell information being recoverable by an analysis means that preferably includes an array photodetector such as a CCD camera and a spectrometer. The apparatus and method may be used to analyze biomedical cells including blood cells and the like, and may include processing means for manipulating, sorting, or eradicating cells after analysis. 20 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 445709
- Patent Number(s):
- 5608519
- Application Number:
- PAN: 8-407,345
- Assignee:
- SNL; SCA: 550300; PA: EDB-97:044183; SN: 97001749874
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 4 Mar 1997
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; CYTOLOGICAL TECHNIQUES; CELL CONSTITUENTS; ANIMAL CELLS; PLANT CELLS; MICROSCOPY; SPECTROSCOPY; LASERS; MEASURING INSTRUMENTS
Citation Formats
Gourley, P L, and Gourley, M F. Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells. United States: N. p., 1997.
Web.
Gourley, P L, & Gourley, M F. Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells. United States.
Gourley, P L, and Gourley, M F. Tue .
"Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells". United States.
@article{osti_445709,
title = {Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells},
author = {Gourley, P L and Gourley, M F},
abstractNote = {An apparatus and method are disclosed for microscopic and spectroscopic analysis and processing of biological cells. The apparatus comprises a laser having an analysis region within the laser cavity for containing one or more biological cells to be analyzed. The presence of a cell within the analysis region in superposition with an activated portion of a gain medium of the laser acts to encode information about the cell upon the laser beam, the cell information being recoverable by an analysis means that preferably includes an array photodetector such as a CCD camera and a spectrometer. The apparatus and method may be used to analyze biomedical cells including blood cells and the like, and may include processing means for manipulating, sorting, or eradicating cells after analysis. 20 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 04 00:00:00 EST 1997},
month = {Tue Mar 04 00:00:00 EST 1997}
}