Method for quantifying optical properties of the human lens
Abstract
A method is disclosed for quantifying optical properties of the human lens. The present invention includes the application of fiberoptic, OMA-based instrumentation as an in vivo diagnostic tool for the human ocular lens. Rapid, noninvasive and comprehensive assessment of the optical characteristics of a lens using very modest levels of exciting light are described. Typically, the backscatter and fluorescence spectra (from about 300- to 900-nm) elicited by each of several exciting wavelengths (from about 300- to 600-nm) are collected within a few seconds. The resulting optical signature of individual lenses is then used to assess the overall optical quality of the lens by comparing the results with a database of similar measurements obtained from a reference set of normal human lenses having various ages. Several metrics have been identified which gauge the optical quality of a given lens relative to the norm for the subject`s chronological age. These metrics may also serve to document accelerated optical aging and/or as early indicators of cataract or other disease processes. 8 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- Sponsoring Org.:
- USDOE, Washington, DC (United States)
- OSTI Identifier:
- 350324
- Patent Number(s):
- 5894340
- Application Number:
- PAN: 8-744,678
- Assignee:
- Univ. of California, Los Alamos, NM (United States)
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 13 Apr 1999
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; MAN; CRYSTALLINE LENS; OPTICAL PROPERTIES; FIBER OPTICS; MEASURING INSTRUMENTS; MEDICINE; CATARACTS; DIAGNOSIS
Citation Formats
Loree, T R, Bigio, I J, Zuclich, J A, Shimada, Tsutomu, and Strobl, K. Method for quantifying optical properties of the human lens. United States: N. p., 1999.
Web.
Loree, T R, Bigio, I J, Zuclich, J A, Shimada, Tsutomu, & Strobl, K. Method for quantifying optical properties of the human lens. United States.
Loree, T R, Bigio, I J, Zuclich, J A, Shimada, Tsutomu, and Strobl, K. Tue .
"Method for quantifying optical properties of the human lens". United States.
@article{osti_350324,
title = {Method for quantifying optical properties of the human lens},
author = {Loree, T R and Bigio, I J and Zuclich, J A and Shimada, Tsutomu and Strobl, K},
abstractNote = {A method is disclosed for quantifying optical properties of the human lens. The present invention includes the application of fiberoptic, OMA-based instrumentation as an in vivo diagnostic tool for the human ocular lens. Rapid, noninvasive and comprehensive assessment of the optical characteristics of a lens using very modest levels of exciting light are described. Typically, the backscatter and fluorescence spectra (from about 300- to 900-nm) elicited by each of several exciting wavelengths (from about 300- to 600-nm) are collected within a few seconds. The resulting optical signature of individual lenses is then used to assess the overall optical quality of the lens by comparing the results with a database of similar measurements obtained from a reference set of normal human lenses having various ages. Several metrics have been identified which gauge the optical quality of a given lens relative to the norm for the subject`s chronological age. These metrics may also serve to document accelerated optical aging and/or as early indicators of cataract or other disease processes. 8 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 13 00:00:00 EDT 1999},
month = {Tue Apr 13 00:00:00 EDT 1999}
}