Methods of making proteins with non-standard amino acids
Abstract
The disclosure provides methods of making a protein having a desired non-standard amino acid incorporated at its N-terminus in a cell and methods of screening for an amino acyl tRNA synthetase variant that preferentially selects a non-standard amino acid against its standard amino acid counterpart or undesired non-standard amino acids for incorporation into a protein in a cell.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1998386
- Patent Number(s):
- 11649450
- Application Number:
- 16/627,077
- Assignee:
- President & Fellows of Harvard College (Cambridge, MA)
- DOE Contract Number:
- FG02-02ER63445
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 06/29/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Kunjapur, Aditya Mohan, and Church, George M. Methods of making proteins with non-standard amino acids. United States: N. p., 2023.
Web.
Kunjapur, Aditya Mohan, & Church, George M. Methods of making proteins with non-standard amino acids. United States.
Kunjapur, Aditya Mohan, and Church, George M. Tue .
"Methods of making proteins with non-standard amino acids". United States. https://www.osti.gov/servlets/purl/1998386.
@article{osti_1998386,
title = {Methods of making proteins with non-standard amino acids},
author = {Kunjapur, Aditya Mohan and Church, George M.},
abstractNote = {The disclosure provides methods of making a protein having a desired non-standard amino acid incorporated at its N-terminus in a cell and methods of screening for an amino acyl tRNA synthetase variant that preferentially selects a non-standard amino acid against its standard amino acid counterpart or undesired non-standard amino acids for incorporation into a protein in a cell.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 16 00:00:00 EDT 2023},
month = {Tue May 16 00:00:00 EDT 2023}
}
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