Title: Microfluidic ultrasonic particle separators with engineered node locations and geometries

Abstract

An ultrasonic microfluidic system includes a separation channel for conveying a sample fluid containing small particles and large particles, flowing substantially parallel, adjacent to a recovery fluid, with which it is in contact. An acoustic transducer produces an ultrasound standing wave, that generates a pressure field having at least one node of minimum pressure amplitude. An acoustic extension structure is located proximate to said separation channel for positioning said acoustic node off center in said acoustic area and concentrating the large particles in said recovery fluid stream.

Inventors:

Rose, Klint A.; Fisher, Karl A.; Wajda, Douglas A.; Mariella, Jr., Raymond P.; Bailey, Christopher; Dehlinger, Dietrich; Shusteff, Maxim; Jung, Byoungsok; Ness, Kevin D.

Issue Date:

Tue Apr 26 00:00:00 EDT 2016

Research Org.:

Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1248912

Patent Number(s):

9321050

Application Number:

14/659,825

Assignee:

Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

B01D21/28 - Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
B01D21/283 - {Settling tanks provided with vibrators}
B01D2221/10 - Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

B01L2200/0631 - Purification arrangements, e.g. solid phase extraction [SPE]
B01L2200/0636 - Focussing flows, e.g. to laminate flows
B01L2200/0652 - Sorting or classification of particles or molecules
B01L2300/0816 - Cards, e.g. flat sample carriers usually with flow in two horizontal directions
B01L2300/0864 - comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
B01L2400/0439 - ultrasonic vibrations, vibrating piezo elements
B01L2400/0487 - fluid pressure, pneumatics
B01L3/50273 - {characterised by the means or forces applied to move the fluids
B01L3/502761 - {specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N1/4077 - {by other techniques involving separation of suspended solids}
G01N2001/4094 - {using ultrasound}
G01N33/48728 - {Investigating individual cells, e.g. by patch clamp, voltage clamp
G01N33/491 - {by separating the blood components

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DOE Contract Number:  

AC52-07NA27344

Resource Type:

Patent

Resource Relation:

Patent File Date: 2015 Mar 17

Country of Publication:

United States

Language:

English

Subject:

42 ENGINEERING; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS