Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
Abstract
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
- Inventors:
- Issue Date:
- Research Org.:
- The Scripps Research Inst., La Jolla, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1223701
- Patent Number(s):
- 9163271
- Application Number:
- 13/475,792
- Assignee:
- The Scripps Research Institute (La Jolla, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- FG03-00ER45812
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 May 18
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Schultz, Peter G., Wang, Lei, Anderson, John Christopher, Chin, Jason W., Liu, David R., Magliery, Thomas J., Meggers, Eric L., Mehl, Ryan Aaron, Pastrnak, Miro, Santoro, Stephen William, and Zhang, Zhiwen. Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs. United States: N. p., 2015.
Web.
Schultz, Peter G., Wang, Lei, Anderson, John Christopher, Chin, Jason W., Liu, David R., Magliery, Thomas J., Meggers, Eric L., Mehl, Ryan Aaron, Pastrnak, Miro, Santoro, Stephen William, & Zhang, Zhiwen. Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs. United States.
Schultz, Peter G., Wang, Lei, Anderson, John Christopher, Chin, Jason W., Liu, David R., Magliery, Thomas J., Meggers, Eric L., Mehl, Ryan Aaron, Pastrnak, Miro, Santoro, Stephen William, and Zhang, Zhiwen. Tue .
"Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs". United States. https://www.osti.gov/servlets/purl/1223701.
@article{osti_1223701,
title = {Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs},
author = {Schultz, Peter G. and Wang, Lei and Anderson, John Christopher and Chin, Jason W. and Liu, David R. and Magliery, Thomas J. and Meggers, Eric L. and Mehl, Ryan Aaron and Pastrnak, Miro and Santoro, Stephen William and Zhang, Zhiwen},
abstractNote = {This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 20 00:00:00 EDT 2015},
month = {Tue Oct 20 00:00:00 EDT 2015}
}
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Works referenced in this record:
L-phenylalanyl-tRNA synthetase mutants, a process for the preparation thereof and the use thereof for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins
patent, December 1994
- Hennecke, Hauke; Kast, Peter
- US Patent Document 5,370,995
Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
patent, March 2004
- Madison, Edwin L.
- US Patent Document 6,706,504
Glycoprotein synthesis
patent, August 2005
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Document 6,927,042
In vivo incorporation of unnatural amino acids
patent, May 2006
- Schultz, Peter G.; Wang, Lei; Anderson, John Christopher
- US Patent Document 7,045,337
Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
patent, August 2006
- Schultz, Peter G.; Wang, Lei; Anderson, John Christopher
- US Patent Document 7,083,970
Glycoprotein synthesis
patent, October 2006
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Document 7,129,333
Glycoprotein synthesis
patent, February 2007
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Document 7,183,082
Glycoprotein synthesis
patent, April 2007
- Shultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Document 7,199,222
Glycoprotein synthesis
patent, May 2007
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Document 7,217,809
Glycoprotein synthesis
patent, July 2007
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Document 7,238,510
Glycoprotein synthesis
patent, August 2007
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Document 7,262,040
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
patent, April 2008
- Schultz, Peter G.; Wang, Lei; Anderson, John Christopher
- US Patent Document 7,354,761
In vivo incorporation of unnatural amino acids
patent, May 2008
- Schultz, Peter G.; Wang, Lei; Anderson, John Christopher
- US Patent Document 7,368,275
In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria
patent, May 2008
- Schultz, Peter G.; Hanson, Sarah R.; Xu, Ran
- US Patent Document 7,378,263
Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination
patent, July 2008
- Xie, Jianming; Wang, Lei; Wu, Ning
- US Patent Document 7,399,619
Site specific incorporation of keto amino acids into proteins
patent, October 2008
- Schultz, Peter G.; Wang, Lei
- US Patent Document 7,432,092
Site-specific incorporation of redox active amino acids into proteins
patent, February 2009
- Alfonta, Lital; Schultz, Peter G.; Zhang, Zhiwen
- US Patent Document 7,494,796
Site specific incorporation of keto amino acids into proteins
patent, April 2009
- Schultz, Peter G.; Wang, Lei
- US Patent Document 7,524,647
Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
patent, May 2009
- Anderson, J. Christopher; Schultz, Peter G.; Santoro, Stephen
- US Patent Document 7,527,943
Glycoprotein synthesis
patent, July 2009
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Document 7,560,535
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
patent, August 2009
- Anderson, J. Christopher; Wu, Ning; Santoro, Stephen
- US Patent Document 7,575,895
Expanding the eukaryotic genetic code
patent, October 2009
- Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher
- US Patent Document 7,608,423
Expanding the eukaryotic genetic code
patent, November 2009
- Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher
- US Patent Document 7,618,775
Expanding the eukaryotic genetic code
patent, December 2009
- Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher
- US Patent Document 7,625,717
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
patent, December 2009
- Anderson, J. Christopher; Wu, Ning; Santoro, Stephen
- US Patent Document 7,638,297
In vivo incorporation of unnatural amino acids
patent, December 2009
- Schultz, Peter G.; Wang, Lei; Anderson, John Christopher
- US Patent Document 7,638,300
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
patent, May 2010
- Zhang, Zhiwen; Alfonta, Lital; Schultz, Peter G.
- US Patent Document 7,709,604
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
patent, May 2010
- Schultz, Peter G.; Wang, Lei; Anderson, John Christopher
- US Patent Document 7,713,721
In vivo incorporation of alkynyl amino acids into proteins in eubacteria
patent, May 2010
- Deiters, Alexander; Schultz, Peter G.
- US Patent Document 7,718,410
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
patent, June 2010
- Zhang, Zhiwen; Alfonta, Lital; Schultz, Peter G.
- US Patent Document 7,741,071
Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
patent, September 2010
- Wang, Jiangyun; Schultz, Peter G.
- US Patent Document 7,790,847
Expanding the eukaryotic genetic code
patent, September 2010
- Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher
- US Patent Document 7,794,978
Genetically encoded fluorescent coumarin amino acids
patent, October 2010
- Wang, Jiangyun; Xie, Jianming; Schultz, Peter G.
- US Patent Document 7,807,411
In vivo incorporation of alkynyl amino acids into proteins in eubacteria
patent, November 2010
- Deiters, Alexander; Schultz, Peter G.
- US Patent Document 7,824,893
Glycoprotein synthesis
patent, November 2010
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Document 7,825,226
Glycoprotein synthesis
patent, November 2010
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Document 7,834,159
patent-application, October 2004
- Schultz, Peter G.; Wang, Lei
- US Patent Application 10/744899; 20040198637
Unnatural reactive amino acid genetic code additions
patent-application, December 2004
- Deiters, Alexander; Cropp, T. Ashton; Chin, Jason W.
- US Patent Application 10/826919; 20040265952
Expanding the eukaryotic genetic code
patent-application, January 2005
- Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher
- US Patent Application 10/825867; 20050009049
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
patent-application, June 2005
- Zhang, Zhiwen; Alfonta, Lital; Schultz, Peter
- US Patent Application 11/016348; 20050136513
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
patent-application, September 2005
- Schultz, Peter; Wang, Lei; Anderson, John Christopher
- US Patent Application 11/009635; 20050208536
Site-specific incorporation of redox active amino acids into proteins
patent-application, October 2005
- Alfonta, Lital; Schultz, Peter G.; Zhang, Zhiwen
- US Patent Application 10/965218; 20050227318
In vivo incorporation of unnatural amino acids
patent-application, November 2005
- Schultz, Peter; Wang, Lei; Anderson, John Christopher
- US Patent Application 11/017550; 20050250183
Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination
patent-application, December 2005
- Xie, Jianming; Wang, Lei; Wu, Ning
- US Patent Application 11/137850; 20050272121
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
patent-application, March 2006
- Schultz, Peter; Wang, Lei; Anderson, John Christopher
- US Patent Application 11/002387; 20060063244
In vivo incorporation of alkynyl amino acids into proteins in eubacteria
patent-application, April 2006
- Deiters, Alexander; Schultz, Peter
- US Patent Application 11/232425; 20060073507
Site-specific labeling of proteins for NMR studies
patent-application, May 2006
- Deiters, Alexander; Geierstanger, Bernhard H.; Schultz, Peter G.
- US Patent Application 11/233466; 20060110784
In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria
patent-application, May 2006
- Schultz, Peter G.; Hanson, Sarah R.; Xu, Ran
- US Patent Application 11/255601; 20060110796
Adding photoregulated amino acids to the genetic code
patent-application, June 2006
- Deiters, Alexander; Wu, Ning; Schultz, Peter G.
- US Patent Application 11/233508; 20060134746
Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
patent-application, July 2006
- Anderson, J. Christopher; Schultz, Peter G.
- US Patent Application 10/563655; 20060160175
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
patent-application, August 2006
- Anderson, J. Christopher; Wu, Ning; Santoro, Stephen
- US Patent Application 11/326970; 20060177900
Unnatural reactive amino acid genetic code additions
patent-application, November 2006
- Deiters, Alexander; Cropp, T. Ashton; Chin, Jason W.
- US Patent Application 10/561121; 20060246509
Site-specific incorporation of redox active amino acids into proteins
patent-application, January 2007
- Alfonta, Lital; Schultz, Peter G.; Zhang, Zhiwen
- US Patent Application 10/575991; 20070009990
Composition of orthogonal glutamyl-trna and aminoacyl-trna synthetase pairs and uses thereof
patent-application, January 2007
- Anderson, J. Christopher; Schultz, Peter G.; Santoro, Stephen
- US Patent Application 10/563656; 20070020634
Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
patent-application, February 2007
- Anderson, J. Christopher; Wu, Ning; Santoro, Stephen
- US Patent Application 10/563686; 20070042461
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
patent-application, May 2007
- Zhang, Zhiwen; Alfonta, Lital; Schultz, Peter
- US Patent Application 10/580987; 20070111193
In vivo incorporation of unnatural amino acids
patent-application, May 2007
- Schultz, Peter; Wang, Lei; Anderson, John Christopher
- US Patent Application 11/583551; 20070117184
Expanding the eukaryotic genetic code
patent-application, July 2007
- Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher
- US Patent Application 11/710655; 20070154952
Expanding the eukaryotic genetic code
patent-application, July 2007
- Chin, Jason; Cropp, T. Ashton; Anderson, J. Christopher
- US Patent Application 11/710672; 20070166791
Glycoprotein synthesis
patent-application, July 2007
- Schultz, Peter; Wang, Lei; Zhang, Zhiwen
- US Patent Application 11/580203; 20070172915
Selective posttranslational modification of phage-displayed polypeptides
patent-application, August 2007
- Tsao, Meng-Lin; Tian, Feng; Schultz, Peter
- US Patent Application 11/580223; 20070178448
Glycoprotein synthesis
patent-application, August 2007
- Schultz, Peter; Wang, Lei; Zhang, Zhiwen
- US Patent Application 11/520849; 20070184517
Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
patent-application, October 2007
- Wang, Jiangyun; Schultz, Peter
- US Patent Application 11/724039; 20070238152
Systems for the expression of orthogonal translation components in eubacterial host cells
patent-application, December 2007
- Ryu, Youngha; Schultz, Peter
- US Patent Application 11/715672; 20070281335
Genetically encoded fluorescent coumarin amino acids
patent-application, February 2008
- Wang, Jiangyun; Xie, Jianming; Schultz, Peter G.
- US Patent Application 11/805247; 20080044886
In Vivo Site-Specific Incorporation of N-Acetyl-Galactosamine Amino Acids in Eubacteria
patent-application, March 2008
- Schultz, Peter G.; Hanson, Sarah R.; Xu, Ran
- US Patent Application 11/664898; 20080064059
Genetically programmed expression of selectively sulfated proteins in eubacteria
patent-application, May 2008
- Liu, Chang C.; Schultz, Peter G.
- US Patent Application 11/903499; 20080113407
Genetic incorporation of unnatural amino acids into proteins in mammalian cells
patent-application, July 2008
- Liu, Wenshe; Schultz, Peter G.
- US Patent Application 11/975351; 20080166766
In vivo incorporation of unnatural amino acids
patent-application, July 2008
- Schultz, Peter; Wang, Lei; Anderson, John Christopher
- US Patent Application 11/800455; 20080166783
In vivo incorporation of unnatural amino acids
patent-application, July 2008
- Schultz, Peter; Wang, Lei; Anderson, John Christopher
- US Patent Application 11/978188; 20080167243
Site-Specific Labeling of Proteins for Nmr Studies
patent-application, July 2008
- Deiters, Alexander; Geierstanger, Bernhard H.; Schultz, Peter G.
- US Patent Application 11/662814; 20080171317
Expanding the eukaryotic genetic code
patent-application, July 2008
- Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher
- US Patent Application 11/978172; 20080176277
Glycoprotein synthesis
patent-application, September 2008
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Application 11/978232; 20080213828
In Vivo Incorporation of Alkynyl Amino Acids into Proteins in Eubacteria
patent-application, September 2008
- Deiters, Alexander; Schultz, Peter G.
- US Patent Application 11/663513; 20080220472
In vivo incorporation of unnatural amino acids
patent-application, September 2008
- Schultz, Peter; Wang, Lei; Anderson, John Christopher
- US Patent Application 11/978156; 20080227152
Site specific incorporation of keto amino acids into proteins
patent-application, September 2008
- Schultz, Peter G.; Wang, Lei
- US Patent Application 11/978182; 20080227153
Expanding the eukaryotic genetic code
patent-application, September 2008
- Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher
- US Patent Application 11/978121; 20080227195
Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids
patent-application, September 2008
- Schultz, Peter G.; Alfonta, Lital; Chittuluru, Jonathan R.
- US Patent Application 11/665083; 20080233611
In vivo site-sepecific incorporation of N-acetyl-galactosamine amino acids in eubacteria
patent-application, October 2008
- Schultz, Peter G.; Hanson, Sarah R.; Xu, Ran
- US Patent Application 12/082214; 20080241903
In vivo incorporation of unnatural amino acids
patent-application, October 2008
- Schultz, Peter; Wang, Lei; Anderson, John Shristopher
- US Patent Application 11/978108; 20080261311
Methods and composition for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
patent-application, February 2009
- Schultz, Peter; Wang, Lei; Anderson, John Christopher
- US Patent Application 11/978221; 20090053791
In vivo incorporation of unnatural amino acids
patent-application, March 2009
- Schultz, Peter; Wang, Lei; Anderson, John Christopher
- US Patent Application 11/978157; 20090068717
Site-specific labeling of proteins for NMR studies
patent-application, March 2009
- Deiters, Alexander; Geierstanger, Bernhard H.; Schultz, Peter G.
- US Patent Application 12/313321; 20090081690
Selective Posttranslational Modification of Phage-Displayed Polypeptides
patent-application, May 2009
- Tsao, Meng-Lin; Tian, Feng; Schultz, Peter
- US Patent Application 11/992341; 20090137424
Genetically Encoded Boronate Amino Acid
patent-application, June 2009
- Brustad, Eric; Bushey, Mark L.; Schultz, Peter G.
- US Patent Application 12/262025; 20090148887
Directed evolution using proteins comprising unnatural amino acids
patent-application, June 2009
- Liu, Chang; Tsao, Meng-Lin; Smider, Vaughn
- US Patent Application 12/290673; 20090163368
Systems for the Expression of Orthogonal Translation Components Eubacterial Host Cells
patent-application, July 2009
- Ryu, Youngha; Schultz, Peter G.
- US Patent Application 12/224773; 20090181429
Adding photoregulated amino acids to the genetic code
patent-application, July 2009
- Deiters, Alexander; Wu, Ning; Schultz, Peter G.
- US Patent Application 11/662749; 20090181858
In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
patent-application, August 2009
- Young, Travis; Schultz, Peter G.
- US Patent Application 12/316370; 20090197339
Genetic Incorporation of 3-Aminotyrosine Into Reductases
patent-application, August 2009
- Seyedsayamdost, Mohammad R.; XIe, Jianming; Clement Chan, Tsz Yan
- US Patent Application 12/257303; 20090208994
Genetically Programmed Expression of Proteins
patent-application, August 2009
- Wang, Jiangyun; Schultz, Peter G.
- US Patent Application 12/225261; 20090209000
Site specific incorporation of keto amino acids into proteins
patent-application, August 2009
- Schultz, Peter G.; Wang, Lei
- US Patent Application 12/228146; 20090215117
Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
patent-application, September 2009
- Schultz, Peter G.; Wang, Lei; Anderson, John Christopher
- US Patent Application 11/978154; 20090227002
Breaking immunological toterance with a genetically encoded unnatural amino acid
patent-application, October 2009
- Grunewald, Jan; Tsao, Meng-Lin; Perera, Roshan
- US Patent Application 12/322938; 20090263376
Genetically programmed expression of selectively sulfated proteins in eubacteria
patent-application, November 2009
- Liu, Chang C.; Schultz, Peter G.
- US Patent Application 12/311169; 20090286279
Genetically encoded coumarin amino acids
patent-application, December 2009
- Wang, Jiangyun; Xie, Jianming; Schultz, Peter G.
- US Patent Application 12/227383; 20090298119
Site-specific incorporation of redox active amino acids into proteins
patent-application, December 2009
- Alfonta, Lital; Schultz, Peter G.; Zhang, Zhiwen
- US Patent Application 12/317034; 20090298124
Glycoprotein synthesis
patent-application, January 2010
- Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
- US Patent Application 12/454390; 20100009425
Genetic incorporation of unnatural amino acids into proteins in mammalian cells
patent-application, January 2010
- Liu, Wenshe; Schultz, Peter G.
- US Patent Application 12/311545; 20100021963
Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
patent-application, November 2010
- Young, Travis; Schultz, Peter G.
- US Patent Application 12/653274; 20100297693
Illicit Transport: The Oligopeptide Permease
journal, February 1973
- Ames, B. N.; Ames, G. F. -L.; Young, J. D.
- Proceedings of the National Academy of Sciences, Vol. 70, Issue 2
Exploring the Limits of Codon and Anticodon Size
journal, February 2002
- Anderson, J. Christopher; Magliery, Thomas J.; Schultz, Peter G.
- Chemistry & Biology, Vol. 9, Issue 2, p. 237-244
Glutamine analogues as potential antimalarials
journal, March 1991
- Azoulay, M.; Vilmont, M.; Frappier, F.
- European Journal of Medicinal Chemistry, Vol. 26, Issue 2, p. 201-205
Biosynthetic site-specific incorporation of a non-natural amino acid into a polypeptide
journal, September 1989
- Bain, J. D.; Diala, Edward S.; Glabe, Charles G.
- Journal of the American Chemical Society, Vol. 111, Issue 20, p. 8013-8014
Synthesis of novel α-amino-acids and derivatives using radical chemistry: synthesis of L- and D-α-amino-adipic acids, L-α
journal, January 1987
- Barton, Derek H. R.; Hervé, Yolande; Potier, Pierre
- Tetrahedron, Vol. 43, Issue 19, p. 4297-4308
Bio–incorporation of telluromethionine into buried residues of dihydrofolate reductase
journal, May 1994
- Boles, Jeffrey O.; Lewinski, Krzysztof; Kunkle, Marci
- Nature Structural & Molecular Biology, Vol. 1, Issue 5, p. 283-284
Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution: Interaction of the enzyme with the tyrosyl adenylate intermediate
journal, July 1989
- Brick, P.; Bhat, T. N.; Blow, D. M.
- Journal of Molecular Biology, Vol. 208, Issue 1, p. 83-98
Glutamine analogues as potential antimalarials
journal, March 1991
- Azoulay, M.; Vilmont, M.; Frappier, F.
- European Journal of Medicinal Chemistry, Vol. 26, Issue 2, p. 201-205
New Photolabeling and Crosslinking Methods
journal, June 1993
- Brunner, Josef
- Annual Review of Biochemistry, Vol. 62, Issue 1
High-level Biosynthetic Substitution of Methionine in Proteins by its Analogs 2-Aminohexanoic Acid, Selenomethionine, Telluromethionine and Ethionine in Escherichia coli
journal, June 1995
- Budisa, Nediljko; Steipe, Boris; Demange, Pascal
- European Journal of Biochemistry, Vol. 230, Issue 2
Bioincorporation of telluromethionine into proteins: a promising new approach for X-ray structure analysis of proteins
journal, July 1997
- Budisa, Nediljko; Karnbrock, Wilhelm; Steinbacher, Stefan
- Journal of Molecular Biology, Vol. 270, Issue 4, p. 616-623
Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers: Structure and stability of the per-thiaproline mutant of annexin V
journal, January 1998
- Budisa, N.; Minks, C.; Medrano, F. J.
- Proceedings of the National Academy of Sciences, Vol. 95, Issue 2
Enzyme-Linked Immunosorbent Assay (Elisa) for Detection of Human Reovirus-like Agent of Infantile Gastroenteritis
journal, August 1977
- Yolken, Robert H.; Kim, HyunWha; Clem, Thomas
- The Lancet, Vol. 310, Issue 8032, p. 263-267
Probing Protein Structure and Function with an Expanded Genetic Code
journal, March 1995
- Cornish, Virginia W.; Mendel, David; Schultz, Peter G.
- Angewandte Chemie International Edition in English, Vol. 34, Issue 6, p. 621-633
Site-Specific Protein Modification Using a Ketone Handle
journal, January 1996
- Cornish, Virginia W.; Hahn, Klaus M.; Schultz, Peter G.
- Journal of the American Chemical Society, Vol. 118, Issue 34, p. 8150-8151
Absolute configuration of the enantiomers of 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline (chloroquine)
journal, March 1988
- Craig, J. Cymerman; Bhargava, Hemendra N.; Everhart, E. Thomas
- The Journal of Organic Chemistry, Vol. 53, Issue 6, p. 1167-1170
Enlarging the Amino Acid Set of Escherichia coli by Infiltration of the Valine Coding Pathway
journal, April 2001
- Doring, V.; Mootz, H. D.; Nangle, L. A.
- Science, Vol. 292, Issue 5516
Unnatural amino acids as probes of protein structure and function
journal, December 2000
- Dougherty, D.
- Current Opinion in Chemical Biology, Vol. 4, Issue 6, p. 645-652
Incorporation of Trifluoromethionine into a Phage Lysozyme: Implications and a New Marker for Use in Protein 19 F NMR †
journal, March 1997
- Duewel, Henry; Daub, Elisabeth; Robinson, Valerie
- Biochemistry, Vol. 36, Issue 11
Crystal structure of the dipeptide binding protein from Escherichia coli involved in active transport and chemotaxis
journal, November 1995
- Dunten, Pete; Mowbray, Sherry L.
- Protein Science, Vol. 4, Issue 11
[15] Biosynthetic method for introducing unnatural amino acids site-specifically into proteins
book, January 1991
- Ellman, Jon; Mendel, David; Anthony-Cahill, Spencer
- Molecular Design and Modeling: Concepts and Applications Part A: Proteins, Peptides, and Enzymes, p. 301-336
Site-specific incorporation of novel backbone structures into proteins
journal, January 1992
- Ellman, J.; Mendel, D.; Schultz, P.
- Science, Vol. 255, Issue 5041
Backbone Mutations in Transmembrane Domains of a Ligand-Gated Ion Channel
journal, January 1999
- England, Pamela M.; Zhang, Yinong; Dougherty, Dennis A.
- Cell, Vol. 96, Issue 1, p. 89-98
Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs
journal, September 1990
- Eriani, Gilbert; Delarue, Marc; Poch, Olivier
- Nature, Vol. 347, Issue 6289, p. 203-206
Major tyrosine identity determinants in Methanococcus jannaschii and Saccharomyces cerevisiae tRNA Tyr are conserved but expressed differently : tRNA identity for
journal, February 2001
- Fechter, Pierre; Rudinger-Thirion, Joëlle; Tukalo, Mikhail
- European Journal of Biochemistry, Vol. 268, Issue 3
Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface.
journal, November 1993
- Francisco, J. A.; Campbell, R.; Iverson, B. L.
- Proceedings of the National Academy of Sciences, Vol. 90, Issue 22
Aminoacyl-tRNA synthetases: Versatile players in the changing theater of translation
journal, November 2002
- Francklyn, Christopher; Perona, John J.; Puetz, Joern
- RNA, Vol. 8, Issue 11
Synthesis of Derivatives of Glutamine as Model Substrates for Anti-tumor Agents
journal, July 1959
- Friedman, Orrie M.; Chatterji, Ramesh
- Journal of the American Chemical Society, Vol. 81, Issue 14, p. 3750-3752
Expansion of the genetic code: Site-directed p-fluoro-phenylalanine incorporation in Escherichia coli
journal, February 1998
- Furter, Rolf
- Protein Science, Vol. 7, Issue 2, p. 419-426
A set of plasmids constitutively producing different RNA levels in Escherichia coli
journal, July 1999
- Gabriel, Kay; McClain, William H.
- Journal of Molecular Biology, Vol. 290, Issue 2
Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins
journal, October 1997
- Gallivan, Justin P.; Lester, Henry A.; Dougherty, Dennis A.
- Chemistry & Biology, Vol. 4, Issue 10, p. 739-749
Modification of the amino acid specificity of tyrosyl-tRNA synthetase by protein engineering
journal, March 1993
- de Prat Gay, Gonzalo; Duckworth, Harry W.; Fersht, Alan R.
- FEBS Letters, Vol. 318, Issue 2, p. 167-171
Aspartate identity of transfer RNAs
journal, January 1996
- Giegé, R.; Florentz, C.; Kern, D.
- Biochimie, Vol. 78, Issue 7, p. 605-623
Universal rules and idiosyncratic features in tRNA identity
journal, November 1998
- Giege, R.; Sissler, M.; Florentz, C.
- Nucleic Acids Research, Vol. 26, Issue 22
Highly Precise Shape Mimicry by a Difluorotoluene Deoxynucleoside, a Replication-Competent Substitute for Thymidine
journal, January 1997
- Guckian, Kevin M.; Kool, Eric T.
- Angewandte Chemie International Edition in English, Vol. 36, Issue 24, p. 2825-2828
A Mutant Escherichia coli Tyrosyl-tRNA Synthetase Utilizes the Unnatural Amino Acid Azatyrosine More Efficiently than Tyrosine
journal, September 2000
- Hamano-Takaku, Fumie; Iwama, Toshiharu; Saito-Yano, Shio
- Journal of Biological Chemistry, Vol. 275, Issue 51, p. 40324-40328
Barnase and barstar: Expression of its cloned inhibitor permits expression of a cloned ribonuclease
journal, August 1988
- Hartley, Robert W.
- Journal of Molecular Biology, Vol. 202, Issue 4, p. 913-915
The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene
journal, October 2001
- Piraee, M.; Magarvey, N.; He, J.
- Microbiology, Vol. 147, Issue 10
Incorporation of Nonnatural Amino Acids Into Proteins
journal, June 2004
- Hendrickson, Tamara L.; Crécy-Lagard, Valérie de; Schimmel, Paul
- Annual Review of Biochemistry, Vol. 73, Issue 1
An unnatural base pair for incorporating amino acid analogs into proteins
journal, February 2002
- Hirao, Ichiro; Ohtsuki, Takashi; Fujiwara, Tsuyoshi
- Nature Biotechnology, Vol. 20, Issue 2
Efficient Incorporation of Nonnatural Amino Acids with Large Aromatic Groups into Streptavidin in In Vitro Protein Synthesizing Systems
journal, January 1999
- Hohsaka, Takahiro; Kajihara, Daisuke; Ashizuka, Yuki
- Journal of the American Chemical Society, Vol. 121, Issue 1
Relaxing the substrate specificity of an aminoacyl-tRNA synthetase allows in vitro and in vivo synthesis of proteins containing unnatural amino acids
journal, May 1995
- Ibba, Michael; Hennecke, Hauke
- FEBS Letters, Vol. 364, Issue 3, p. 272-275
Substrate Specificity Is Determined by Amino Acid Binding Pocket Size in Escherichia coli Phenylalanyl-tRNA Synthetase
journal, June 1994
- Ibba, Michael; Kast, Peter; Hennecke, Hauke
- Biochemistry, Vol. 33, Issue 23
Strategies for in vitro and in vivo translation with non-natural amino acids
journal, December 1996
- Ibba, Michael
- Biotechnology and Genetic Engineering Reviews, Vol. 13, Issue 1
Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme
journal, July 1998
- Jeruzalmi, David; Steitz, Thomas A.
- The EMBO Journal, Vol. 17, Issue 14
Protein-protein interaction: a genetic selection for compensating mutations at the barnase-barstar interface.
journal, March 1996
- Jucovic, M.; Hartley, R. W.
- Proceedings of the National Academy of Sciences, Vol. 93, Issue 6
A cell-free protein synthesis system as an investigational tool for the translation stop processes
journal, April 2002
- Kang, Taek Jin; Woo, Ji Hyoung; Song, Hui Kyoung
- FEBS Letters, Vol. 517, Issue 1-3, p. 211-214
An engineered Escherichia coli tyrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system
journal, July 2002
- Kiga, D.; Sakamoto, K.; Kodama, K.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 15, p. 9715-9720
Protein Engineering by In Vivo Incorporation of Non-Natural Amino Acids: Control of Incorporation of Methionine Analogues by Methionyl-tRNA Synthetase
journal, November 2000
- Kiick, Kristi L.; Tirrell, David A.
- Tetrahedron, Vol. 56, Issue 48, p. 9487-9493
693. A new synthesis of glutamine and of γ-dipeptides of glutamic acid from phthalylated intermediates
journal, January 1949
- King, F. E.; Kidd, D. A. A.
- J. Chem. Soc., Vol. 0, Issue 0
Human Tyrosyl-tRNA Synthetase Shares Amino Acid Sequence Homology with a Putative Cytokine
journal, May 1997
- Kleeman, Theresa A.; Wei, Dongbing; Simpson, Keith L.
- Journal of Biological Chemistry, Vol. 272, Issue 22
Construction of Escherichia coli amber suppressor tRNA genes: II. Synthesis of additional tRNA genes and improvement of suppressor efficiency
journal, June 1990
- Kleina, Lynn G.; Masson, Jean-Michel; Normanly, Jennifer
- Journal of Molecular Biology, Vol. 213, Issue 4, p. 705-717
Synthetically modified DNAs as substrates for polymerases
journal, December 2000
- Kool, E.
- Current Opinion in Chemical Biology, Vol. 4, Issue 6, p. 602-608
Synthesis of 4-substituted prolines as conformationally constrained amino acid analogs
journal, April 1989
- Koskinen, Ari M. P.; Rapoport, Henry
- The Journal of Organic Chemistry, Vol. 54, Issue 8
Exploiting unassigned codons in Micrococcus luteus for tRNA-based amino acid mutagenesis
journal, November 1997
- Kowal, A.
- Nucleic Acids Research, Vol. 25, Issue 22
Twenty-first aminoacyl-tRNA synthetase-suppressor tRNA pairs for possible use in site-specific incorporation of amino acid analogues into proteins in eukaryotes and in eubacteria
journal, January 2001
- Kowal, A. K.; Kohrer, C.; RajBhandary, U. L.
- Proceedings of the National Academy of Sciences, Vol. 98, Issue 5, p. 2268-2273
Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.
journal, November 1986
- Krieg, U. C.; Walter, P.; Johnson, A. E.
- Proceedings of the National Academy of Sciences, Vol. 83, Issue 22
Evolutionary relationship between Halobacterium cutirubrum and eukaryotes determined by use of aminoacyl-tRNA synthetases as phylogenetic probes
journal, March 1980
- Kwok, Yau; Wong, J. Tze-Fei
- Canadian Journal of Biochemistry, Vol. 58, Issue 3
Novel Biological Process for L-DOPA Production from L-Tyrosine by P-Hydroxyphenylacetate 3-Hydroxylase
journal, January 1998
- Lee, Jang-Young; Xun, Luying
- Biotechnology Letters, Vol. 20, Issue 5, p. 479-482
Progress toward the evolution of an organism with an expanded genetic code
journal, April 1999
- Liu, David R.; Schultz, Peter G.
- Proceedings of the National Academy of Sciences, Vol. 96, Issue 9, p. 4780-4785
Characterization of an ‘orthogonal’ suppressor tRNA derived from E. coli tRNA2Gln
journal, September 1997
- Liu, David R.; Magliery, Thomas J.; Schultz, Peter G.
- Chemistry & Biology, Vol. 4, Issue 9, p. 685-691
Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo
journal, September 1997
- Liu, D. R.; Magliery, T. J.; Pastrnak, M.
- Proceedings of the National Academy of Sciences, Vol. 94, Issue 19
Enzyme-generated intracellular fluorescence for single-cell reporter gene analysis utilizing Escherichia coli β-glucuronidase
journal, August 1996
- Lorincz, Matthew; Roederer, Mario; Diwu, Zhenjun
- Cytometry, Vol. 24, Issue 4, p. 321-329
Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter
journal, March 2001
- Lu, Tao; Ting, Alice Y.; Mainland, Joel
- Nature Neuroscience, Vol. 4, Issue 3
In vitro protein engineering using synthetic tRNAAla with different anticodons
journal, August 1993
- Ma, Chunhua; Kudlicki, Wieslaw; Odom, O. W.
- Biochemistry, Vol. 32, Issue 31
Expanding the genetic code: selection of efficient suppressors of four-base codons and identification of “shifty” four-base codons with a library approach in Escherichia coli
journal, March 2001
- Magliery, Thomas J.; Anderson, J. Christopher; Schultz, Peter G.
- Journal of Molecular Biology, Vol. 307, Issue 3, p. 755-769
Differences in Backbone Structure between Angiotensin II Agonists and Type I Antagonists
journal, November 1995
- Matsoukas, John M.; Agelis, George; Wahhab, Amal
- Journal of Medicinal Chemistry, Vol. 38, Issue 23
Efforts toward Expansion of the Genetic Alphabet: DNA Polymerase Recognition of a Highly Stable, Self-Pairing Hydrophobic Base
journal, December 1999
- McMinn, Dustin L.; Ogawa, Anthony K.; Wu, Yiqin
- Journal of the American Chemical Society, Vol. 121, Issue 49
A Novel Copper-Mediated DNA Base Pair
journal, November 2000
- Meggers, Eric; Holland, Patrick L.; Tolman, William B.
- Journal of the American Chemical Society, Vol. 122, Issue 43, p. 10714-10715
Site-Directed Mutagenesis with an Expanded Genetic Code
journal, June 1995
- Mendel, D.; Cornish, V. W.; Schultz, P. G.
- Annual Review of Biophysics and Biomolecular Structure, Vol. 24, Issue 1
Flash Decaging of Tyrosine Sidechains in an Ion Channel
journal, April 1998
- Miller, Jeffrey C.; Silverman, Scott K.; England, Pamela M.
- Neuron, Vol. 20, Issue 4, p. 619-624
Noninvasive Tracing of Recombinant Proteins with “Fluorophenylalanine-Fingers”
journal, August 2000
- Minks, Caroline; Huber, Robert; Moroder, Luis
- Analytical Biochemistry, Vol. 284, Issue 1
Quadruplet codons: implications for code expansion and the specification of translation step size
journal, April 2000
- Moore, Barry; Persson, Britt C.; Nelson, Chad C.
- Journal of Molecular Biology, Vol. 298, Issue 2
Mutational Analysis of Invariant Valine B12 in Insulin: Implications for Receptor Binding
journal, November 2000
- Nakagawa, Satoe H.; Tager, Howard S.; Steiner, Donald F.
- Biochemistry, Vol. 39, Issue 51
2 .ANG. Resolution Structure of DppA, a Periplasmic Dipeptide Transport/Chemosensory Receptor
journal, December 1995
- Nickitenko, Alexei V.; Trakhanov, Sergei; Quiocho, Florante A.
- Biochemistry, Vol. 34, Issue 51
A synthetic IgG-binding domain based on staphylococcal protein A
journal, January 1987
- Nilsson, Björn; Moks, Tomas; Jansson, Birger
- "Protein Engineering, Design and Selection", Vol. 1, Issue 2
A general method for site-specific incorporation of unnatural amino acids into proteins
journal, April 1989
- Noren, C.; Anthony-Cahill, S.; Griffith, M.
- Science, Vol. 244, Issue 4901
Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells
journal, April 1995
- Nowak, M.; Kearney, P.
- Science, Vol. 268, Issue 5209
Rational Design of an Unnatural Base Pair with Increased Kinetic Selectivity
journal, September 2000
- Ogawa, Anthony K.; Wu, Yiqin; Berger, Markus
- Journal of the American Chemical Society, Vol. 122, Issue 36, p. 8803-8804
Efforts toward the Expansion of the Genetic Alphabet: Information Storage and Replication with Unnatural Hydrophobic Base Pairs
journal, April 2000
- Ogawa, Anthony K.; Wu, Yiqin; McMinn, Dustin L.
- Journal of the American Chemical Society, Vol. 122, Issue 14
Co-Expression of Yeast Amber Suppressor tRNATyr and Tyrosyl-tRNA Synthetase in Escherichia coli: Possibility to Expand the Genetic Code
journal, December 1998
- Ohno, S.; Yokogawa, T.; Fujii, I.
- Journal of Biochemistry, Vol. 124, Issue 6
Changing the Amino Acid Specificity of Yeast Tyrosyl-tRNA Synthetase by Genetic Engineering
journal, September 2001
- Ohno, S.; Yokogawa, T.; Nishikawa, K.
- Journal of Biochemistry, Vol. 130, Issue 3
Glycine tRNA mutants with normal anticodon loop size cause -1 frameshifting.
journal, October 1989
- O'Mahony, D. J.; Mims, B. H.; Thompson, S.
- Proceedings of the National Academy of Sciences, Vol. 86, Issue 20
Phage selection for site-specific incorporation of unnatural amino acids into proteins in vivo
journal, September 2001
- Pastrnak, M.
- Bioorganic & Medicinal Chemistry, Vol. 9, Issue 9, p. 2373-2379
A New Orthogonal Suppressor tRNA/Aminoacyl-tRNA Synthetase Pair for Evolving an Organism with an Expanded Genetic Code
journal, September 2000
- Pastrnak, Miro; Magliery, Thomas J.; Schultz, Peter G.
- Helvetica Chimica Acta, Vol. 83, Issue 9, p. 2277-2286
Transport and Hydrolysis of Antibacterial Peptide Analogues in Escherichia coli: Backbone-modified Aminoxy Peptides
journal, September 1984
- Payne, J. W.; Morley, J. S.; Armitage, P.
- Microbiology, Vol. 130, Issue 9
Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet
journal, January 1990
- Piccirilli, Joseph A.; Benner, Steven A.; Krauch, Tilman
- Nature, Vol. 343, Issue 6253
An Engineered Tetrahymena tRNA Gln for in Vivo Incorporation of Unnatural Amino Acids into Proteins by Nonsense Suppression
journal, September 1996
- Saks, Margaret E.; Sampson, Jeffrey R.; Nowak, Mark W.
- Journal of Biological Chemistry, Vol. 271, Issue 38
Directed evolution of the site specificity of Cre recombinase
journal, March 2002
- Santoro, S. W.; Schultz, P. G.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 7, p. 4185-4190
An efficient system for the evolution of aminoacyl-tRNA synthetase specificity
journal, September 2002
- Santoro, Stephen W.; Wang, Lei; Herberich, Brad
- Nature Biotechnology, Vol. 20, Issue 10
5′–3′ Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis
journal, January 1988
- Sayers, Jon R.; Schmidt, Walter; Eckstein, Fritz
- Nucleic Acids Research, Vol. 16, Issue 3
Unprotected Peptides as Building Blocks for the Synthesis of Peptide Dendrimers with Oxime, Hydrazone, and Thiazolidine Linkages
journal, April 1995
- Shao, Jun; Tam, James P.
- Journal of the American Chemical Society, Vol. 117, Issue 14, p. 3893-3899
Efficient introduction of aryl bromide functionality into proteins in vivo
journal, February 2000
- Sharma, Nandita; Furter, Rolf; Kast, Peter
- FEBS Letters, Vol. 467, Issue 1, p. 37-40
Region of a Conserved Sequence Motif in a Class II tRNA Synthetase Needed for Transfer of an Activated Amino Acid to an RNA Substrate
journal, May 1994
- Shi, Jian-Ping; Musier-Forsyth, Karin; Schimmel, Paul
- Biochemistry, Vol. 33, Issue 17
Libraries of hybrid proteins from distantly related sequences
journal, May 2001
- Sieber, Volker; Martinez, Carlos A.; Arnold, Frances H.
- Nature Biotechnology, Vol. 19, Issue 5
Compilation of tRNA sequences and sequences of tRNA genes
journal, January 1998
- Sprinzl, Mathias; Horn, Carsten; Brown, Melissa
- Nucleic Acids Research, Vol. 26, Issue 1, p. 148-153
Major Anticodon-binding Region Missing from an Archaebacterial tRNA Synthetase
journal, December 1999
- Steer, Brian A.; Schimmel, Paul
- Journal of Biological Chemistry, Vol. 274, Issue 50
Quisqualic acid analogs: synthesis of .beta.-heterocyclic 2-aminopropanoic acid derivatives and their activity at a novel quisqualate-sensitized site
journal, November 1992
- Subasinghe, Nalin; Schulte, Marvin; Roon, Robert J.
- Journal of Medicinal Chemistry, Vol. 35, Issue 24
Crystal structure of yeast phenylalanine transfer RNA: I. Crystallographic refinement
journal, August 1978
- Sussman, Joel L.; Holbrook, Stephen R.; Warrant, R. Wade
- Journal of Molecular Biology, Vol. 123, Issue 4, p. 607-630
Enzymatic incorporation of a new base pair into DNA and RNA
journal, October 1989
- Switzer, Christopher; Moroney, Simon E.; Benner, Steven A.
- Journal of the American Chemical Society, Vol. 111, Issue 21, p. 8322-8323
Efforts toward Expansion of the Genetic Alphabet: Replication of DNA with Three Base Pairs
journal, August 2001
- Tae, Eunju Lee; Wu, Yiqin; Xia, Gang
- Journal of the American Chemical Society, Vol. 123, Issue 30
Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability
journal, April 2001
- Tang, Yi; Ghirlanda, Giovanna; Petka, Wendy A.
- Angewandte Chemie International Edition, Vol. 40, Issue 8
Probing the Structure and Function of the Tachykinin Neurokinin-2 Receptor through Biosynthetic Incorporation of Fluorescent Amino Acids at Specific Sites
journal, August 1996
- Turcatti, Gerardo; Nemeth, Karin; Edgerton, Michael D.
- Journal of Biological Chemistry, Vol. 271, Issue 33
Efficient introduction of alkene functionality into proteins in vivo
journal, May 1998
- van Hest, Jan C. M.; Tirrell, David A.
- FEBS Letters, Vol. 428, Issue 1-2, p. 68-70
Efficient Incorporation of Unsaturated Methionine Analogues into Proteins in Vivo
journal, February 2000
- van Hest, Jan C. M.; Kiick, Kristi L.; Tirrell, David A.
- Journal of the American Chemical Society, Vol. 122, Issue 7
Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant
journal, January 1998
- Wakasugi, K.
- The EMBO Journal, Vol. 17, Issue 1
A general approach for the generation of orthogonal tRNAs
journal, September 2001
- Wang, Lei; Schultz, Peter G.
- Chemistry & Biology, Vol. 8, Issue 9, p. 883-890
A New Functional Suppressor tRNA/Aminoacyl−tRNA Synthetase Pair for the in Vivo Incorporation of Unnatural Amino Acids into Proteins
journal, May 2000
- Wang, Lei; Magliery, Thomas J.; Liu, David R.
- Journal of the American Chemical Society, Vol. 122, Issue 20, p. 5010-5011
Expanding the Genetic Code of Escherichia coli
journal, April 2001
- Wang, L.; Brock, A.; Herberich, B.
- Science, Vol. 292, Issue 5516, p. 498-500
Adding l-3-(2-Naphthyl)alanine to the Genetic Code of E. coli
journal, March 2002
- Wang, Lei; Brock, Ansgar; Schultz, Peter G.
- Journal of the American Chemical Society, Vol. 124, Issue 9, p. 1836-1837
A binding protein for l-glutamine and its relation to active transport in E. coli
journal, February 1971
- Weiner, Joel H.; Furlong, Clement E.; Heppel, Leon A.
- Archives of Biochemistry and Biophysics, Vol. 142, Issue 2, p. 715-717
Rescuing an essential enzyme-RNA complex with a non-essential appended domain
journal, May 1997
- Whelihan, E. F.
- The EMBO Journal, Vol. 16, Issue 10
Translational efficiency of transfer RNA's: uses of an extended anticodon
journal, November 1982
- Yarus, M.
- Science, Vol. 218, Issue 4573
Quantitation of Transcription and Clonal Selection of Single Living Cells with -Lactamase as Reporter
journal, January 1998
- Zlokarnik, G.
- Science, Vol. 279, Issue 5347
Aminoacyl-tRNA synthetases database
journal, January 2001
- Szymanski, M.
- Nucleic Acids Research, Vol. 29, Issue 1
IA, database of known ligands of aminoacyl-tRNA synthetases
journal, September 2007
- Torchala, Mieczyslaw; Hoffmann, Marcin
- Journal of Computer-Aided Molecular Design, Vol. 21, Issue 9
A New Functional Suppressor tRNA/Aminoacyl−tRNA Synthetase Pair for the in Vivo Incorporation of Unnatural Amino Acids into Proteins
journal, May 2000
- Wang, Lei; Magliery, Thomas J.; Liu, David R.
- Journal of the American Chemical Society, Vol. 122, Issue 20, p. 5010-5011