Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling
Abstract
A non-aqueous single pot synthesis of [.sup.18F]SFB is set forth. The [.sup.18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California, Oakland, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1207285
- Patent Number(s):
- 9096647
- Application Number:
- 13/924,397
- Assignee:
- The Regents Of The University Of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- FG02-06ER64249
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2013 Jun 21
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Olma, Sebastian, and Shen, Clifton Kwang-Fu. Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling. United States: N. p., 2015.
Web.
Olma, Sebastian, & Shen, Clifton Kwang-Fu. Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling. United States.
Olma, Sebastian, and Shen, Clifton Kwang-Fu. Tue .
"Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling". United States. https://www.osti.gov/servlets/purl/1207285.
@article{osti_1207285,
title = {Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling},
author = {Olma, Sebastian and Shen, Clifton Kwang-Fu},
abstractNote = {A non-aqueous single pot synthesis of [.sup.18F]SFB is set forth. The [.sup.18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 04 00:00:00 EDT 2015},
month = {Tue Aug 04 00:00:00 EDT 2015}
}
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Works referenced in this record:
Recent progress in fluorine-18 labelled peptide radiopharmaceuticals
journal, April 2001
- Okarvi, S.
- European Journal of Nuclear Medicine, Vol. 28, Issue 7
Synthesis of Sildenafil Analogues from Anacardic Acid and Their Phosphodiesterase-5 Inhibition
journal, December 2002
- Paramashivappa, R.; Phani Kumar, P.; Subba Rao, P. V.
- Journal of Agricultural and Food Chemistry, Vol. 50, Issue 26
Facile synthesis ofN-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) for protein labeling
journal, January 2008
- Tang, G.; Zeng, Wenbin; Yu, Meixiang
- Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 51, Issue 1
Radiolabelling of isopeptide Nε-(γ-glutamyl)-l-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate
journal, July 2003
- Wüst, F.; Hultsch, C.; Bergmann, R.
- Applied Radiation and Isotopes, Vol. 59, Issue 1, p. 43-48