Title: Engineered microbes and methods for microbial oil overproduction from cellulosic materials

Abstract

The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.

Inventors:

Stephanopoulos, Gregory; Tai, Mitchell

Issue Date:

Tue Aug 04 00:00:00 EDT 2015

Research Org.:

Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1207280

Patent Number(s):

9096876

Application Number:

13/923,607

Assignee:

Massachusetts Institute of Technology (Cambridge, MA)

Patent Classifications (CPCs):

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N9/0006 - {acting on CH-OH groups as donors
C12N9/92 - Glucose isomerase {

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P2203/00 - Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source
C12P7/6463 - {obtained from glyceride producing microorganisms, e.g. single cell oil}
C12P7/649 - {Biodiesel, i.e. Fatty acid alkyl esters}

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

C12Y101/01009 - D-Xylulose reductase
C12Y101/0101 - L-Xylulose reductase
C12Y101/01307 - D-Xylose reductase
C12Y503/01005 - Xylose isomerase

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION

Y02E50/10 - Biofuels

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DOE Contract Number:  

AR0000059

Resource Type:

Patent

Resource Relation:

Patent File Date: 2013 Jun 21

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES