Peptides whose uptake by cells is controllable

Jiang, Tao; Olson, Emilia S.; Whitney, Michael; Tsien, Roger

Advanced Search OptionsAdvanced Search queries use a traditional Term Search. For more info, see our FAQ.

All Fields:

Patent Title:

Abstract:

Assignee:

Inventor(s):

Patent Number:

Patent Classification (CPC):

All Classifications
A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
A41 - wearing apparel
A42 - headwear
A43 - footwear
A44 - haberdashery
A45 - hand or travelling articles
A46 - brushware
A47 - furniture
A61 - medical or veterinary science
A62 - life-saving
A63 - sports
A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
B02 - crushing, pulverising, or disintegrating
B03 - separation of solid materials using liquids or using pneumatic tables or jigs
B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
B05 - spraying or atomising in general
B06 - generating or transmitting mechanical vibrations in general
B07 - separating solids from solids
B08 - cleaning
B09 - disposal of solid waste
B21 - mechanical metal-working without essentially removing material
B22 - casting
B23 - machine tools
B24 - grinding
B25 - hand tools
B26 - hand cutting tools
B27 - working or preserving wood or similar material
B28 - working cement, clay, or stone
B29 - working of plastics
B30 - presses
B31 - making articles of paper, cardboard or material worked in a manner analogous to paper
B32 - layered products
B33 - additive manufacturing technology
B41 - printing
B42 - bookbinding
B43 - writing or drawing implements
B44 - decorative arts
B60 - vehicles in general
B61 - railways
B62 - land vehicles for travelling otherwise than on rails
B63 - ships or other waterborne vessels
B64 - aircraft
B65 - conveying
B66 - hoisting
B67 - opening, closing {or cleaning} bottles, jars or similar containers
B68 - saddlery
B81 - microstructural technology
B82 - nanotechnology
B99 - subject matter not otherwise provided for in this section
C - chemistry
C01 - inorganic chemistry
C02 - treatment of water, waste water, sewage, or sludge
C03 - glass
C04 - cements
C05 - fertilisers
C06 - explosives
C07 - organic chemistry
C08 - organic macromolecular compounds
C09 - dyes
C10 - petroleum, gas or coke industries
C11 - animal or vegetable oils, fats, fatty substances or waxes
C12 - biochemistry
C13 - sugar industry
C14 - skins
C21 - metallurgy of iron
C22 - metallurgy
C23 - coating metallic material
C25 - electrolytic or electrophoretic processes
C30 - crystal growth
C40 - combinatorial technology
C99 - subject matter not otherwise provided for in this section
D - textiles
D01 - natural or man-made threads or fibres
D02 - yarns
D03 - weaving
D04 - braiding
D05 - sewing
D06 - treatment of textiles or the like
D07 - ropes
D10 - indexing scheme associated with sublasses of section d, relating to textiles
D21 - paper-making
D99 - subject matter not otherwise provided for in this section
E - fixed constructions
E01 - construction of roads, railways, or bridges
E02 - hydraulic engineering
E03 - water supply
E04 - building
E05 - locks
E06 - doors, windows, shutters, or roller blinds in general
E21 - earth drilling
E99 - subject matter not otherwise provided for in this section
F - mechanical engineering
F01 - machines or engines in general
F02 - combustion engines
F03 - machines or engines for liquids
F04 - positive - displacement machines for liquids
F05 - indexing schemes relating to engines or pumps in various subclasses of classes f01-f04
F15 - fluid-pressure actuators
F16 - engineering elements and units
F17 - storing or distributing gases or liquids
F21 - lighting
F22 - steam generation
F23 - combustion apparatus
F24 - heating
F25 - refrigeration or cooling
F26 - drying
F27 - furnaces
F28 - heat exchange in general
F41 - weapons
F42 - ammunition
F99 - subject matter not otherwise provided for in this section
G - physics
G01 - measuring
G02 - optics
G03 - photography
G04 - horology
G05 - controlling
G06 - computing
G07 - checking-devices
G08 - signalling
G09 - education
G10 - musical instruments
G11 - information storage
G12 - instrument details
G16 - information and communication technology [ict] specially adapted for specific application fields
G21 - nuclear physics
G99 - subject matter not otherwise provided for in this section
H - electricity
H01 - basic electric elements
H02 - generation
H03 - basic electronic circuitry
H04 - electric communication technique
H05 - electric techniques not otherwise provided for
H99 - subject matter not otherwise provided for in this section
Y - new / cross sectional technologies
Y02 - technologies or applications for mitigation or adaptation against climate change
Y04 - information or communication technologies having an impact on other technology areas
Y10 - technical subjects covered by former uspc

More Options ...

Title: Peptides whose uptake by cells is controllable

Abstract

A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

Inventors:: Jiang, Tao; Olson, Emilia S.; Whitney, Michael; Tsien, Roger

Issue Date:: Tue Jul 07 00:00:00 EDT 2015

Research Org.:: Univ. of California, Oakland, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1190922

Patent Number(s):: 9072792

Application Number:: 13/155,168

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Show more

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/00 - Medicinal preparations containing peptides
A61K41/0095 - {Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins}
A61K47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K47/645 - {Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT}
A61K47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
A61K49/0032 - {Methine dyes, e.g. cyanine dyes}
A61K49/0043 - {Fluorescein, used in vivo}
A61K49/0056 - {Peptides, proteins, polyamino acids}
A61K49/085 - {conjugated systems}
A61K49/14 - Peptides, e.g. proteins
A61K49/146 - {the peptide being a polyamino acid, e.g. poly-lysine}
A61K51/088 - {conjugates with carriers being peptides, polyamino acids, proteins

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P35/00 - Antineoplastic agents

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/00 - Peptides having more than 20 amino acids
C07K14/4728 - {Calcium binding proteins, e.g. calmodulin}
C07K7/08 - having 12 to 20 amino acids

Show less

DOE Contract Number:: FG03-01ER63276

Resource Type:: Patent

Resource Relation:: Patent File Date: 2011 Jun 07

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Jiang, Tao, Olson, Emilia S., Whitney, Michael, and Tsien, Roger. Peptides whose uptake by cells is controllable.  United States: N. p., 2015. 
        Web.

Copy to clipboard


                    Jiang, Tao, Olson, Emilia S., Whitney, Michael, & Tsien, Roger. Peptides whose uptake by cells is controllable.  United States.

Copy to clipboard


                    Jiang, Tao, Olson, Emilia S., Whitney, Michael, and Tsien, Roger. Tue .  
        "Peptides whose uptake by cells is controllable".  United States.  https://www.osti.gov/servlets/purl/1190922.

Copy to clipboard


                    
@article{osti_1190922,

  title        = {Peptides whose uptake by cells is controllable},

  author       = {Jiang, Tao and Olson, Emilia S. and Whitney, Michael and Tsien, Roger},

  abstractNote = {A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jul 07 00:00:00 EDT 2015},

  month        = {Tue Jul 07 00:00:00 EDT 2015}

}

Copy to clipboard

Patent:

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Peptide substrates for mammalian collagenase
patent, August 1984

Weingarten, Harold I.
US Patent Document 4,466,919
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4466919

Determination of collagenase by reacting with peptide substrates
patent, March 1985

Weingarten, Harold I.
US Patent Document 4,507,389
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4507389

Fusion protein comprising tat-derived transport moiety
patent, October 1997

Frankel, Alan; Pabo, Carl O.; Barsoum, James
US Patent Document 5,674,980
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5674980

Tat-derived transport polypeptide conjugates
patent, May 1998

Frankel, Alan; Pabo, Carl O.; Barsoum, James
US Patent Document 5,747,641
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5747641

Amphiphilic linkers for coupling administrable diagnostically or physiologically active agents and bioselective targeting compounds
patent, June 1999

Tournier, Herve; Pochon, Sibylle; Lamy, Bernard
US Patent Document 5,910,300
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5910300

Method and composition for enhancing transport across biological membranes
patent, October 2001

Rothbard, Jonathan B.; Wender, Paul A.
US Patent Document 6,306,993
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6306993

Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
patent, February 2002

Piwnica-Worms, David
US Patent Document 6,348,185
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6348185