Ion sensing method
Abstract
The present invention allows the determination of trace levels of ionic substances in a sample solution (ions, metal ions, and other electrically charged molecules) by coupling a separation method, such as liquid chromatography, with ion selective electrodes (ISE) prepared so as to allow detection at activities below 10.sup.-6 M. The separation method distributes constituent molecules into fractions due to unique chemical and physical properties, such as charge, hydrophobicity, specific binding interactions, or movement in an electrical field. The separated fractions are detected by means of the ISE(s). These ISEs can be used singly or in an array. Accordingly, modifications in the ISEs are used to permit detection of low activities, specifically, below 10.sup.-6 M, by using low activities of the primary analyte (the molecular species which is specifically detected) in the inner filling solution of the ISE. Arrays constructed in various ways allow flow-through sensing for multiple ions.
- Inventors:
- Issue Date:
- Research Org.:
- IA INC, Ann Arbor, MI (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1174847
- Patent Number(s):
- 6736958
- Application Number:
- 09/836,542
- Assignee:
- IA INC (Ann Arbor, MI)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- FG02-00ER83019
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Smith, Richard Harding, and Martin, Glenn Brian. Ion sensing method. United States: N. p., 2004.
Web.
Smith, Richard Harding, & Martin, Glenn Brian. Ion sensing method. United States.
Smith, Richard Harding, and Martin, Glenn Brian. Tue .
"Ion sensing method". United States. https://www.osti.gov/servlets/purl/1174847.
@article{osti_1174847,
title = {Ion sensing method},
author = {Smith, Richard Harding and Martin, Glenn Brian},
abstractNote = {The present invention allows the determination of trace levels of ionic substances in a sample solution (ions, metal ions, and other electrically charged molecules) by coupling a separation method, such as liquid chromatography, with ion selective electrodes (ISE) prepared so as to allow detection at activities below 10.sup.-6 M. The separation method distributes constituent molecules into fractions due to unique chemical and physical properties, such as charge, hydrophobicity, specific binding interactions, or movement in an electrical field. The separated fractions are detected by means of the ISE(s). These ISEs can be used singly or in an array. Accordingly, modifications in the ISEs are used to permit detection of low activities, specifically, below 10.sup.-6 M, by using low activities of the primary analyte (the molecular species which is specifically detected) in the inner filling solution of the ISE. Arrays constructed in various ways allow flow-through sensing for multiple ions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 18 00:00:00 EDT 2004},
month = {Tue May 18 00:00:00 EDT 2004}
}
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Works referenced in this record:
Potentiometric detection of inorganic anions and cations in capillary electrophoresis with coated-wire ion-selective electrodes
journal, September 1997
- Kappes, Thomas; Schnierle, Peter; Hauser, Peter C.
- Analytica Chimica Acta, Vol. 350, Issue 1-2
Nonlinear calibration of ion-selective electrode arrays for flow injection analysis
journal, August 1992
- Forster, Robert J.; Diamond, Dermot.
- Analytical Chemistry, Vol. 64, Issue 15
Lowering the Detection Limit of Solvent Polymeric Ion-Selective Membrane Electrodes. 2. Influence of Composition of Sample and Internal Electrolyte Solution
journal, March 1999
- Sokalski, Tomasz; Ceresa, Alan; Fibbioli, Monia
- Analytical Chemistry, Vol. 71, Issue 6
Determination of monovalent cations by ion chromatography with ion-selective electrode detection
journal, October 1983
- Suzuki, Koji.; Aruga, Hiroshi.; Shirai, Tsuneo.
- Analytical Chemistry, Vol. 55, Issue 12
Potentiometric pH detection in suppressed ion chromatography
journal, April 1989
- Trojanowicz, Marek.; Meyerhoff, Mark E.
- Analytical Chemistry, Vol. 61, Issue 7
Fast determination of anions by computerized ion chromatography coupled with selective detectors
journal, September 1981
- Slanina, J.; Bakker, F. P.; Jongejan, P. A. C.
- Analytica Chimica Acta, Vol. 130, Issue 1
Lowering the Detection Limit of Solvent Polymeric Ion-Selective Electrodes. 1. Modeling the Influence of Steady-State Ion Fluxes
journal, March 1999
- Sokalski, Tomasz; Zwickl, Titus; Bakker, Eric
- Analytical Chemistry, Vol. 71, Issue 6
Direct and replacement ion chromatography with potentiometric detection using a silver/silver bromide electrode
journal, January 1989
- Trojanowicz, Marek; Pobozy, Ewa; Meyerhoff, Mark E.
- Analytica Chimica Acta, Vol. 222, Issue 1
Potentiometric detection in ion chromatography using multi-ionophore membrane electrodes
journal, October 1993
- Hyun Han, Sang; Shin Lee, Kang; Sig Cha, Geun
- Journal of Chromatography A, Vol. 648, Issue 1
Replacement ion chromatography with potentiometric detection using a potassium-selective membrane electrode
journal, January 1989
- Trojanowicz, Marek; Meyerhoff, Mark E.
- Analytica Chimica Acta, Vol. 222, Issue 1
Lead-selective bulk optodes based on neutral ionophores with subnanomolar detection limits
journal, July 1992
- Lerchi, Markus.; Bakker, Eric.; Rusterholz, Bruno.
- Analytical Chemistry, Vol. 64, Issue 14