Amphiphiles for protein solubilization and stabilization
Abstract
The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
- Inventors:
- Issue Date:
- Research Org.:
- Wisconsin Aumni Research Foundation, Madison, WI (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1163212
- Patent Number(s):
- 8877906
- Application Number:
- 13/608,385
- Assignee:
- Wisconsin Aumni Research Foundation (Madison, WI)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
- DOE Contract Number:
- W-31-109-ENG38
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Sep 10
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Phillip D, and Wander, Marc J. Amphiphiles for protein solubilization and stabilization. United States: N. p., 2014.
Web.
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Phillip D, & Wander, Marc J. Amphiphiles for protein solubilization and stabilization. United States.
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Phillip D, and Wander, Marc J. Tue .
"Amphiphiles for protein solubilization and stabilization". United States. https://www.osti.gov/servlets/purl/1163212.
@article{osti_1163212,
title = {Amphiphiles for protein solubilization and stabilization},
author = {Gellman, Samuel Helmer and Chae, Pil Seok and Laible, Phillip D and Wander, Marc J},
abstractNote = {The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 04 00:00:00 EST 2014},
month = {Tue Nov 04 00:00:00 EST 2014}
}
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Works referenced in this record:
Amphiphilic agents for membrane protein solubilization
patent, January 2001
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Synthetic Amphiphiles for Membrane Protein Manipulation
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journal, July 2008
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Works referencing / citing this record:
Amphiphiles for protein solubilization and stabilization
patent, November 2014
- Gellman, Samuel H.; Chae, Pil Seok; Laible, Phillip D.
- US Patent Document 8,877,906