DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Ultrasonic analyte concentration and application in flow cytometry

Abstract

The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1149911
Patent Number(s):
8783109
Application Number:
11/982,042
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 2007 Oct 31
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Kaduchak, Gregory, Goddard, Greg, Salzman, Gary, Sinha, Dipen, Martin, John C., Kwiatkowski, Christopher, and Graves, Steven. Ultrasonic analyte concentration and application in flow cytometry. United States: N. p., 2014. Web.
Kaduchak, Gregory, Goddard, Greg, Salzman, Gary, Sinha, Dipen, Martin, John C., Kwiatkowski, Christopher, & Graves, Steven. Ultrasonic analyte concentration and application in flow cytometry. United States.
Kaduchak, Gregory, Goddard, Greg, Salzman, Gary, Sinha, Dipen, Martin, John C., Kwiatkowski, Christopher, and Graves, Steven. Tue . "Ultrasonic analyte concentration and application in flow cytometry". United States. https://www.osti.gov/servlets/purl/1149911.
@article{osti_1149911,
title = {Ultrasonic analyte concentration and application in flow cytometry},
author = {Kaduchak, Gregory and Goddard, Greg and Salzman, Gary and Sinha, Dipen and Martin, John C. and Kwiatkowski, Christopher and Graves, Steven},
abstractNote = {The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 22 00:00:00 EDT 2014},
month = {Tue Jul 22 00:00:00 EDT 2014}
}

Works referenced in this record:

Material suspension within an acoustically excited resonant chamber
patent, May 1975


Remote acoustic wave sensors
patent, May 1981


Method and apparatus for field flow fractionation
patent, August 1981


Antibody production from hybrid cell line
patent, September 1982


Human nonsecretory plasmacytoid cell line
patent, February 1984


Acoustic particle separation
patent, June 1985


Screening method for red cell abnormality
patent, June 1986


Particle separation
patent, June 1987


Manipulation of particles
patent, May 1988


Methods and apparatus for moving and separating materials exhibiting different physical properties
patent, July 1988


Controlled sample orientation and rotation in an acoustic levitator
patent, October 1988


Biological sample mixing apparatus and method
patent, July 1989


Manipulating particulate matter
patent, October 1989


Particle agglutination immunoassay apparatus
patent, April 1990


Acoustic positioning and orientation prediction
patent, October 1990


Method for analysis of subpopulations of cells
patent, January 1991


Chemiluminescence-based static and flow cytometry
patent, July 1991


Analyzing system using sheath flow of sample
patent, January 1992


Acoustically driven particle separation method and apparatus
patent, February 1992


Method and apparatus for separating particles
patent, July 1993


Bioluminescence bathyphotometer
patent, November 1993


Phthalocyanine and tetrabenztriazaporphyrin reagents
patent, September 1994


Control of flow cytometer having vacuum fluidics
patent, March 1995


Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry
patent, April 1996


Multilayered piezoelectric resonator for the separation of suspended particles
patent, June 1996


Particle analyzer with spatially split wavelength filter
patent, June 1996


Apparatus and method for volumetric capillary cytometry
patent, August 1996


Acoustic filter for separating and recycling suspended particles
patent, May 1997


Up-converting reporters for biological and other assays using laser excitation techniques
patent, October 1997


Method and apparatus for separating particulate from a flowing fluid
patent, November 1997


Flow cell apparatus
patent, November 1997


Multilayered piezoelectric resonator for the separation of suspended particles
patent, January 1998


Liquid flow cytometer
patent, April 1998


High solid infrared absorbing compositions
patent, September 1998


Method of non-contact micromanipulation using ultrasound
patent, November 1998


Multiplexed analysis of clinical specimens apparatus and methods
patent, November 1999


Non-contact micromanipulation method and apparatus
patent, May 2000


Synthetic polymer particles for use as standards and calibrators in flow cytometry
patent, June 2000


Method and apparatus for acoustically demixing aqueous solutions
patent, July 2000


Method for enumerating blood cells
patent, March 2001


Particle handling apparatus for handling particles in fluid by acoustic radiation pressure
patent, April 2001


Method and apparatus for acoustically driven media filtration
patent, April 2001


Method and apparatus for analyzing cells in a whole blood sample
patent, May 2001


Method and apparatus for flow cytometry
patent, June 2001


Method for using an all solid-state fluorometer in industrial water system applications
patent, July 2001


High throughput analysis of samples in flowing liquid
patent, October 2001


Particle manipulation
patent, December 2001


Aerodynamic beam generator for large particles
patent, February 2002


Dispersive near-IR Raman spectrometer
patent, April 2002


Cylindrical acoustic levitator/concentrator
patent, October 2002


Measuring the velocity of small moving objects such as cells
patent, March 2003


Optical detection system for flow cytometry
patent, April 2003


Focusing of microparticles in microfluidic systems
patent, July 2003


Low acceleration method of flow cytometry
patent, August 2003


Ice making machine
patent, November 2003


Fluorescence detection instrument with reflective transfer legs for color decimation
patent, January 2004


Flow cytometer
patent, March 2004


Method and apparatus for acoustically driven media filtration
patent, September 2004


Methods, compositions, and automated systems for separating rare cells from fluid samples
patent, September 2005


Ultrasonically cleaned membrane filtration system
patent, March 2006


Consumable tube for use with a flow cytometry-based hematology system
patent, June 2006


Methods for manipulating moieties in microfluidic systems
patent, July 2006


Fluorescent dyes, energy transfer couples and methods
patent, August 2006


Method and apparatus for separating particles by size
patent, September 2006


Methods, compositions, and automated systems for separating rare cells from fluid samples
patent, January 2007


Imaging and analyzing parameters of small moving objects such as cells
patent, January 2008


Methods for sampling a liquid flow
patent, February 2008


Apparatus for directing particles in a fluid
patent, May 2008


Flow cytometer
patent, January 2009


System for analyzing particles using multiple flow cytometry units
patent, July 2010


Flow cytometer and flow cytometry
patent, August 2011


Method and apparatus for the generation of ultrasonic energy fields within circular structures containing a liquid
patent-application, September 2002


Cylindrical Acoustic Levitator/Concentrator
patent-application, November 2002


Nucleic acid sequencing by raman monitoring of molecular deconstruction
patent-application, March 2003


Fluorescence proximity assay
patent-application, March 2003


Laser diode-excited biological particle detection system
patent-application, May 2003


System and method for sterilization of a liquid
patent-application, March 2004


Method and apparatus for separating particles by size
patent-application, April 2004


Device and method for separation
patent-application, April 2004


Ultrasonic monitor of material composition and particle size
patent-application, July 2004


Dielectric particle focusing
patent-application, April 2005


Ultrasonic flow meter and ultrasonic sensor
patent-application, May 2005


Laser machining of electroactive ceramics
patent-application, January 2006


Ultrasonic analyte concentration and application in flow cytometry
patent-application, February 2006


Separation of particles from a fluid by wave action
patent-application, February 2006


Ultrasonic transducer and manufacturing method thereof
patent-application, April 2006


Apparatus for moving particles from a first fluid to a second fluid
patent-application, July 2006


Ultrasonic concentration of carrier particles
patent-application, March 2007


Using Optical Scattering to Measure Properties of Ultrasound Contrast Agent Shells
patent-application, May 2007


Method and apparatus for determination of the concentration of particles in multi-component fluid systems
patent-application, May 2007


Compact efficient and robust ultraviolet
patent-application, November 2007


Acoustic/Pressure Wave-Driven Separation Device
patent-application, March 2008


System and method for measuring particles in a sample stream of a flow cytometer or the like
patent-application, May 2008


Apparatus for separating particles utilizing engineered acoustic contrast capture particles
patent-application, October 2008


Acoustic concentration of particles in fluid flow
patent-application, October 2008


Particle Analyzing Systems and Methods Using Acoustic Radiation Pressure
patent-application, January 2009


Device and Method for Noninvasive Ultrasonic Treatment of Fluids and Materials in Conduits and Cylindrical Containers
patent-application, February 2009


Particle Fusing Systems and Methods Using Acoustic Radiation Pressure
patent-application, February 2009


Particle Quantifying Systems and Methods Using Acoustic Radiation Pressure
patent-application, February 2009


Kits for Systems and Methods Using Acoustic Radiation Pressure
patent-application, February 2009


Particle Imaging Systems and Methods Using Acoustic Radiation Pressure
patent-application, February 2009


Medium Switching Systems and Methods Using Acoustic Radiation Pressure
patent-application, February 2009


Particle Switching Systems and Methods Using Acoustic Radiation Pressure
patent-application, February 2009


Method for Non-Contact Particle Manipulation and Control of Particle Spacing Along on Axis
patent-application, April 2009


Method for non-contact particle manipulation and control of particle spacing along an axis
patent-application, June 2009


Particle analysis in an acoustic cytometer
patent-application, June 2009


Particle analysis in an acoustic cytometer
patent-application, June 2009


System and Method for Acoustic Focusing Hardware and Implementations
patent-application, July 2009


Coustic Concentration Method and Device and a Reaction Method
patent-application, September 2009


Dynamic Characterization of Particles with Flow Cytometry
patent-application, December 2009


Methods for Acoustic Particle Focusing in Biological Sample Analyzers
patent-application, January 2010


Acoustic Concentration of Particles in Fluid Flow
patent-application, February 2011


System and Method for Measuring Particles in a Sample Stream of a Flow Cytometer or the Like
patent-application, February 2011


Apparatuses, Systems, Methods, And Computer Readable Media For Acoustic Flow Cytometry.
patent-application, June 2011


Migration of suspended particles in plane stationary ultrasonic field
journal, January 1981


A micro-particle positioning technique combining an ultrasonic manipulator and a microgripper
journal, June 2006


Acoustic radiation potential on a sphere in plane, cylindrical, and spherical standing wave fields
journal, March 1985


Formation and growth of ice particles in stationary ultrasonic fields
journal, September 1998


Inorganic phosphors as new luminescent labels for immunocytochemistry and time-resolved microscopy
journal, January 1990


Microchip-Based Cell Lysis and DNA Extraction from Sperm Cells for Application to Forensic Analysis
journal, March 2006


Comparative analysis of whole blood lysis methods for flow cytometry
journal, June 1997


Analytical scale ultrasonic standing wave manipulation of cells and microparticles
journal, March 2000


Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: I. Concept and theoretical evaluation
journal, July 1994


Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: II. Instrument design and experimental results
journal, July 1994


Hydrodynamic orientation of sperm heads for flow cytometry
journal, July 1978


A Novel Ultrasonic Resonance Field Device for the Retention of Animal Cells
journal, July 1994


Major signal increase in fluorescence microscopy through dark-state relaxation
journal, December 2006


Classification of Spectroscopically Encoded Resins by Raman Mapping and Infrared Hyperspectral Imaging
journal, March 2006


Hydrodynamic orientation of cells.
journal, July 1977


Selective Retention of Viable Cells in Ultrasonic Resonance Field Devices
journal, February 1996


Quantum Dot-Encoded Mesoporous Beads with High Brightness and Uniformity:  Rapid Readout Using Flow Cytometry
journal, April 2004


Single particle high resolution spectral analysis flow cytometry
journal, January 2006


Ultrasonic particle concentration in a line-driven cylindrical tube
journal, June 2005


Ultrasonic particle-concentration for sheathless focusing of particles for analysis in a flow cytometer
journal, January 2006


Acoustically driven collection of suspended particles within porous media
journal, March 1997


Fractionation of mixed particulate solids according to compressibility using ultrasonic standing wave fields
journal, October 1995


Positioning of small particles by an ultrasound field excited by surface waves
journal, April 2004


An analytical system based on a compact flow cytometer for DNA fragment sizing and single-molecule detection
journal, January 2004


Near-Infrared Photo- and Electroluminescence of Alkoxy-Substituted Poly p-phenylene) and Nonconjugated Polymer/Lanthanide Tetraphenylporphyrin Blends
journal, July 2004


Ultrasonic deposition of cells on a surface
journal, April 2004


Progress in Lanthanides as Luminescent Probes
journal, July 2005


Fluorescence background discrimination by prebleaching.
journal, January 1979


High throughput particle analysis: Combining dielectrophoretic particle focussing with confocal optical detection
journal, February 2006


Synthesis, Characterization, and Application of Eu(III), Tb(III), Sm(III), and Dy(III) Lanthanide Chelate Nanoparticle Labels
journal, April 2005


Cellular platforms for HTS: three case studies
journal, March 2002


Particle separation using ultrasound can be used with human shed mediastinal blood
journal, January 2005


Spatial light-scattering analysis as a means of characterizing and classifying non-spherical particles
journal, February 1998


On the Acoustic Radiation Pressure on Spheres
journal, November 1934


Acoustic concentration of particles in piezoelectric tubes: Theoretical modeling of the effect of cavity shape and symmetry breaking
journal, October 2004

  • Kogan, Shulim; Kaduchak, Gregory; Sinha, Dipen N.
  • The Journal of the Acoustical Society of America, Vol. 116, Issue 4, p. 1967-1974
  • https://doi.org/10.1121/1.1785613

Fractionation of cell mixtures using acoustic and laminar flow fields
journal, January 2004


Increasing the luminescence of lanthanide complexes
journal, January 2006


Acoustic Positioning for Space Processing of Materials Science Samples in Mirror Furnaces
conference, January 1983


Cell discrimination by multiangle light scattering.
journal, January 1976


Identification of cell asymmetry and orientation by light scattering.
journal, July 1977


Scanning flow cytometry for individual particle analysis
journal, January 2000


Acoustic filtration and sedimentation of soot particles
journal, December 1997


Particle Characterization and Separation by a Coupled Acoustic−Gravity Field
journal, July 2001


Optimization of high-sensitivity fluorescence detection
journal, September 1990


Separation of a biocatalyst with ultrafiltration or filtration after bioconversion
journal, March 1997


The Small-Angle Light Scattering of Biological Cells: Theoretical Considerations
journal, August 1970


Angular distribution of light scattered by single biological cells and oriented particle agglomerates
journal, January 2003


Carrier Medium Exchange through Ultrasonic Particle Switching in Microfluidic Channels
journal, March 2005


Free Flow Acoustophoresis:  Microfluidic-Based Mode of Particle and Cell Separation
journal, July 2007


Multifunctional Encoded Particles for High-Throughput Biomolecule Analysis
journal, March 2007


Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry
journal, December 2002


A numerically stable global matrix method for cylindrically layered shells excited by ring forces
journal, June 1994


Seven-Color Time-Resolved Fluorescence Hybridization Analysis of Human Papilloma Virus Types
journal, November 1997


Measurement of Mammalian Erythrocyte Indices from Light Scattering with Scaning Flow Cytometer
conference, January 2003


Continuous Flow Microfluidic Device for Rapid Erythrocyte Lysis
journal, November 2004


Book Reviews
journal, April 1989


Individual Escherichia coli cells studied from light scattering with the scanning flow cytometer
journal, January 2000


Light-scattering properties of individual erythrocytes
journal, January 1999


New types of microspheres and microsphere-related materials for medical diagnostics
journal, October 2002

  • Slomkowski, Stanislaw; Basinska, Teresa; Miksa, Beata
  • Polymers for Advanced Technologies, Vol. 13, Issue 10-12, p. 905-918
  • https://doi.org/10.1002/pat.283

Data Analysis for a Dual-Channel Virus Counter
journal, April 2005


Design and characterization of a compact dual channel virus counter
journal, January 2005


A means for orienting flat cells in flow systems
journal, July 1978


Compact acoustic levitation device for studies in fluid dynamics and material science in the laboratory and microgravity
journal, November 1985


PDMS-based opto-fluidic micro flow cytometer with two-color, multi-angle fluorescence detection capability using PIN photodiodes
journal, March 2004


Strategy for selection of methods for separation of bioparticles from particle mixtures
journal, January 2006


Retention and Viability Characteristics of Mammalian Cells in an Acoustically Driven Polymer Mesh
journal, January 2004


Extension of acoustic levitation to include the study of micron‐size particles in a more compressible host liquid
journal, May 1982


Particle column formation in a stationary ultrasonic field
journal, January 1992


Transport and harvesting of suspended particles using modulated ultrasound
journal, November 1991


Diazo Coupling Method for Covalent Attachment of Proteins to Solid Substrates
journal, March 2006


Micro particle trapping by opposite phases ultrasonic travelling waves
journal, July 1998


Blood Concentration by Superposition of Higher Harmonics of Ultrasound
journal, May 1997


Using acoustic radiation force as a concentration method for erythrocytes
journal, July 1997

  • Yasuda, Kenji; Haupt, Stephan Shuichi; Umemura, Shin-ichiro
  • The Journal of the Acoustical Society of America, Vol. 102, Issue 1, p. 642-645
  • https://doi.org/10.1121/1.421009

Preparation of three terbium complexes with p-aminobenzoic acid and investigation of crystal structure influence on luminescence property
journal, October 2004


Experimental and theoretical study of light scattering by individual mature red blood cells by use of scanning flow cytometry and a discrete dipole approximation
journal, January 2005


Mathematical modeling of the movement of suspended particles subjected to acoustic and flow fields
journal, June 2005


Ultrasonic separation in microfluidic capillaries
conference, January 2003


Physical enviroment of 2-D animal cell aggregates formed in a short pathlength ultrasound standing wave trap
journal, March 2005


Improved quartz crystal microbalance technique
journal, August 1984


Development of a novel compact sonicator for cell disruption
journal, February 2005


Ultrasound, a new separation technique to harvest microalgae
journal, March 2003


Cell–cell contact and membrane spreading in an ultrasound trap
journal, April 2004


Ultrasonic separations in analytical biotechnology
journal, December 1997


Plasma preparation from whole blood using ultrasound
journal, June 2000


Dynamics of suspended particles in a two-dimensional high-frequency sonic field
journal, June 1995


Side drift of aerosols in two-dimensional resonant acoustic levitators
journal, November 1997


Mean force on a small sphere in a sound field in a viscous fluid
journal, January 2000


The mean force acting on a small body in an axisymmetric sound field in a real medium
journal, January 1987


Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. I. General formula
journal, February 1997


Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. II. Force on a rigid sphere
journal, February 1997


Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. III. Force on a liquid drop
journal, February 1997


Acoustic Radiation Pressure on a Rigid Sphere in a Viscous Fluid
journal, December 1994


A new immobilisation method to arrange particles in a gel matrix by ultrasound standing waves
journal, February 2005


Precise Measurements Of Particle Entrainment In A Standing-Wave Acoustic Field Between 20 And 3500 Hz
journal, December 2000


Upper sound pressure limits on particle concentration in fields of ultrasonic standing-wave at megahertz frequencies
journal, January 1992


Single fiber model of particle retention in an acoustically driven porous mesh
journal, March 2003


Single-collector experiments and modeling of acoustically aided mesh filtration
journal, January 2005


Transport analysis and model for the performance of an ultrasonically enhanced filtration process
journal, June 2005


Contactless micromanipulation of small particles by an ultrasound field excited by a vibrating body
journal, May 2005


Manipulation of cells using an ultrasonic pressure field
journal, June 2005


Acoustic streaming generated by standing waves in two-dimensional channels of arbitrary width
journal, January 2003

  • Hamilton, Mark F.; Ilinskii, Yurii A.; Zabolotskaya, Evgenia A.
  • The Journal of the Acoustical Society of America, Vol. 113, Issue 1, p. 153-160
  • https://doi.org/10.1121/1.1528928

Linear and nonlinear frequency shifts in acoustical resonators with varying cross sections
journal, July 2001

  • Hamilton, Mark F.; Ilinskii, Yurii A.; Zabolotskaya, Evgenia A.
  • The Journal of the Acoustical Society of America, Vol. 110, Issue 1, p. 109-119
  • https://doi.org/10.1121/1.1379080

A silicon microfluidic ultrasonic separator
journal, October 2003


Effect of Process Parameters on Ultrasonic Separation of Dispersed Particles in Liquid
journal, May 1999


Force field particle filter, combining ultrasound standing waves and laminar flow
journal, May 2001


Microparticle manipulation in millimetre scale ultrasonic standing wave chambers
journal, August 1998


Single half-wavelength ultrasonic particle filter: Predictions of the transfer matrix multilayer resonator model and experimental filtration results
journal, March 2002

  • Hawkes, Jeremy J.; Coakley, W. Terence; Gröschl, Martin
  • The Journal of the Acoustical Society of America, Vol. 111, Issue 3, p. 1259-1266
  • https://doi.org/10.1121/1.1448341

Standing‐wave acoustic trap for nonintrusive positioning of microparticles
journal, October 1995


Modelling in the design of a flow-through ultrasonic separator
journal, March 2000


Modelling of layered resonators for ultrasonic separation
journal, May 2002


Operating Characteristics of Acoustically Driven Filtration Processes for Particulate Suspensions
journal, January 2000


The selection of layer thicknesses to control acoustic radiation force profiles in layered resonators
journal, January 2003


The use of ultrasonic standing waves to enhance optical particle sizing equipment
journal, March 2000


E6 diffraction catastrophe of the primary rainbow of oblate water drops: observations with white-light and laser illumination
journal, January 1994


Continuous particle size separation and size sorting using ultrasound in a microchannel
journal, January 2006


Field-assisted extraction of cells, particles and macromolecules
journal, February 2002


Enhanced sedimentation of mammalian cells following acoustic aggregation
journal, August 1989


Acoustic micromanipulation using a multi-electrode transducer
conference, January 1996


Control of a Standing Wave Field Using a Line-Focused Transducer for Two-Dimensional Manipulation of Particles
journal, May 1998


Micromanipulation using a focused ultrasonic standing wave field
journal, January 2000


Cavitation bubble-driven cell and particle behavior in an ultrasound standing wave
journal, January 2005

  • Kuznetsova, Larisa A.; Khanna, Sanjay; Amso, Nazar N.
  • The Journal of the Acoustical Society of America, Vol. 117, Issue 1, p. 104-112
  • https://doi.org/10.1121/1.1835503

Microparticle concentration in short path length ultrasonic resonators: Roles of radiation pressure and acoustic streaming
journal, October 2004


Resonator frequency shift due to ultrasonically induced microparticle migration in an aqueous suspension: Observations and model for the maximum frequency shift
journal, June 1998

  • Kwiatkowski, Christopher S.; Marston, Philip L.
  • The Journal of the Acoustical Society of America, Vol. 103, Issue 6, p. 3290-3300
  • https://doi.org/10.1121/1.423080

Trapping of microparticles in the near field of an ultrasonic transducer
journal, March 2005


Theory of long wavelength acoustic radiation pressure
journal, October 1991


Enhanced synchronized ultrasonic and flow-field fractionation of suspensions
journal, March 1994


Manipulation of Fluid Objects with Acoustic Radiation Pressure
journal, January 2006


SPART analyzer: its application to aerodynamic size distribution measurement
journal, January 1979


Single particle aerodynamic relaxation time analyzer
journal, June 1977


Manipulation of in vitro toxicant sensors in an ultrasonic standing wave
journal, February 2004


Design, modeling and characterization of microfluidic devices for ultrasonic manipulation
journal, February 2007


Acoustic control of suspended particles in micro fluidic chips
journal, January 2004


Layered piezoelectric resonators with an arbitrary number of electrodes (general one‐dimensional treatment)
journal, September 1991

  • Nowotny, Helmut; Benes, Ewald; Schmid, Michael
  • The Journal of the Acoustical Society of America, Vol. 90, Issue 3, p. 1238-1245
  • https://doi.org/10.1121/1.401915

Acoustically aided separation of oil droplets from aqueous emulsions
journal, August 2004


Continuous separation of lipid particles from erythrocytes by means of laminar flow and acoustic standing wave forces
journal, January 2005


Batch and semicontinuous aggregation and sedimentation of hybridoma cells by acoustic resonance fields
journal, March 1995


Oscillational instabilities in single‐mode acoustic levitators
journal, January 1990


Micro-organism manipulation and microparticle arrangement by the use of ultrasonic standing waves
conference, November 2001


Ultrasonic manipulation of locomotive microorganisms and evaluation of their activity
journal, December 2002


Ultrasonic trapping of paramecia and estimation of their locomotive force
journal, October 1997


Ultrasonic waves for fabricating lattice structure in composite materials
conference, September 1999

  • Saito, Mitsunori; Itagaki, Kazuhiro; Imanishi, Yoshihiro
  • SPIE's International Symposium on Optical Science, Engineering, and Instrumentation
  • https://doi.org/10.1117/12.363793

Quantum mechanical representation of acoustic streaming and acoustic radiation pressure
journal, July 2001


A computer-controlled system for the measurement of complete admittance spectra of piezoelectric resonators
journal, September 1990


Ultrasonic four‐wave mixing mediated by an aqueous suspension of microspheres: Theoretical steady‐state properties
journal, September 1995


Sub-micron particle manipulation in an ultrasonic standing wave: Applications in detection of clinically important biomolecules
journal, January 2000


Ultrasonic Micromanipulation of Small Particles in Liquid
journal, May 1994


Ultrasonic Micromanipulator Using Visual Feedback
journal, May 1996


Separation devices based on forced coincidence response of fluid‐filled pipes
journal, June 1992


Separation of dispersed phases from liquids in acoustically driven chambers
journal, February 1993


Modelling of particle paths passing through an ultrasonic standing wave
journal, April 2004


Experimental study of streaming flows associated with ultrasonic levitators
journal, November 1994


Trapping of heavy gases in stationary ultrasonic fields
journal, September 2002


On the drift of aerosol particles in sonic fields
journal, September 1992


The effect of centreline particle concentration in a wave tube
journal, January 1996


Microfluidic tools for biological sample preparation
conference, January 2002


Concentration and Fractionation of Small Particles in Liquid by Ultrasound
journal, May 1995


Deoxyribonucleic acid concentration using acoustic radiation force
journal, February 1996

  • Yasuda, Kenji; Kiyama, Masaharu; Umemura, Shin‐ichiro
  • The Journal of the Acoustical Society of America, Vol. 99, Issue 2, p. 1248-1251
  • https://doi.org/10.1121/1.414635

Non-destructive, non-contact handling method for biomaterials in micro-chamber by ultrasound
journal, June 2000


Particle separation using acoustic radiation force and elecrostatic force
journal, April 1996

  • Yasuda, Kenji; Umemura, Shin‐ichiro; Takeda, Kazuo
  • The Journal of the Acoustical Society of America, Vol. 99, Issue 4, p. 1965-1970
  • https://doi.org/10.1121/1.415382

Blue LED Excitable Temperature Sensors Based on a New Europium(III) Chelate
journal, February 2008


On the Possibility of Long-Wavelength Long-Lifetime High-Quantum-Yield Luminophores
journal, January 2001


Dual-laser, differential fluorescence correction method for reducing cellular background autofluorescence
journal, November 1986


Resolving leukocytes using axial light loss
journal, July 1989


Lanthanide-based luminescence probes and time-resolved luminescence bioassays
journal, May 2006


Pulsed laser fluorescence spectrometer
journal, October 1987


Electroacoustic production of murine hybridomas
journal, May 1990


Acoustic Radiation Pressure of Plane Compressional Waves
journal, July 1953


Acoustic separation in a laminar flow
conference, January 1994


Impedance spectroscopy flow cytometry: On-chip label-free cell differentiation
journal, January 2005


Positioning, displacement, and localization of cells using ultrasonic forces
journal, January 2005


Coincidence in high-speed flow cytometry: Models and measurements
journal, January 1991


Ueber longitudinale Schwingungen und Klangfiguren in cylindrischen Flüssigkeitssäulen
journal, January 1874


Tensile strength and visible ultrasonic cavitation of superfluid4He
journal, November 1976


Use of acoustic radiation pressure to concentrate small particles in an air flow
conference, January 2002


    Works referencing / citing this record: