Title: Microbial engineering for the production of fatty acids and fatty acid derivatives

Abstract

Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.

Inventors:

Stephanopoulos, Gregory; Abidi, Syed Hussain Imam

Issue Date:

Tue Jul 01 00:00:00 EDT 2014

Research Org.:

Massachusetts Institute of Technology, Cambridge, MA (USA)

Sponsoring Org.:

USDOE

OSTI Identifier:

1136742

Patent Number(s):

8765404

Application Number:

13/039,227

Assignee:

Massachusetts Institute of Technology (Cambridge, MA)

Patent Classifications (CPCs):

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N15/815 - {for yeasts other than Saccharomyces}
C12N9/001 - {acting on the CH-CH group of donors
C12N9/0071 - {acting on paired donors with incorporation of molecular oxygen

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P7/6409 - {Fatty acids}
C12P7/6463 - {obtained from glyceride producing microorganisms, e.g. single cell oil}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION

Y02E50/10 - Biofuels

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DOE Contract Number:  

FC36-07GO17058

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

09 BIOMASS FUELS; 60 APPLIED LIFE SCIENCES