Solid phase sequencing of biopolymers
Abstract
This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Probes may be affixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.
- Inventors:
- Issue Date:
- Research Org.:
- Sequenom, Inc., San Diego, CA (USA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1135918
- Patent Number(s):
- 8758995
- Application Number:
- 12/852,336
- Assignee:
- Sequenom, Inc. (San Diego, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- FG02-93ER61609
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 Aug 06
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Cantor, Charles R., and Koster, Hubert. Solid phase sequencing of biopolymers. United States: N. p., 2014.
Web.
Cantor, Charles R., & Koster, Hubert. Solid phase sequencing of biopolymers. United States.
Cantor, Charles R., and Koster, Hubert. Tue .
"Solid phase sequencing of biopolymers". United States. https://www.osti.gov/servlets/purl/1135918.
@article{osti_1135918,
title = {Solid phase sequencing of biopolymers},
author = {Cantor, Charles R. and Koster, Hubert},
abstractNote = {This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Probes may be affixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 24 00:00:00 EDT 2014},
month = {Tue Jun 24 00:00:00 EDT 2014}
}
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