Methods for the synthesis of deuterated vinyl pyridine monomers
Abstract
Methods for synthesizing deuterated vinylpyridine compounds of the Formula (1), wherein the method includes: (i) deuterating an acyl pyridine of the Formula (2) in the presence of a metal catalyst and D.sub.2O, wherein the metal catalyst is active for hydrogen exchange in water, to produce a deuterated acyl compound of Formula (3); (ii) reducing the compound of Formula (3) with a deuterated reducing agent to convert the acyl group to an alcohol group, and (iii) dehydrating the compound produced in step (ii) with a dehydrating agent to afford the vinylpyridine compound of Formula (1). The resulting deuterated vinylpyridine compounds are also described.
- Inventors:
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1125020
- Patent Number(s):
- 8658802
- Application Number:
- 13/553,293
- Assignee:
- UT-Battelle, LLC (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Hong, Kunlun, Yang, Jun, and Bonnesen, Peter V. Methods for the synthesis of deuterated vinyl pyridine monomers. United States: N. p., 2014.
Web.
Hong, Kunlun, Yang, Jun, & Bonnesen, Peter V. Methods for the synthesis of deuterated vinyl pyridine monomers. United States.
Hong, Kunlun, Yang, Jun, and Bonnesen, Peter V. Tue .
"Methods for the synthesis of deuterated vinyl pyridine monomers". United States. https://www.osti.gov/servlets/purl/1125020.
@article{osti_1125020,
title = {Methods for the synthesis of deuterated vinyl pyridine monomers},
author = {Hong, Kunlun and Yang, Jun and Bonnesen, Peter V},
abstractNote = {Methods for synthesizing deuterated vinylpyridine compounds of the Formula (1), wherein the method includes: (i) deuterating an acyl pyridine of the Formula (2) in the presence of a metal catalyst and D.sub.2O, wherein the metal catalyst is active for hydrogen exchange in water, to produce a deuterated acyl compound of Formula (3); (ii) reducing the compound of Formula (3) with a deuterated reducing agent to convert the acyl group to an alcohol group, and (iii) dehydrating the compound produced in step (ii) with a dehydrating agent to afford the vinylpyridine compound of Formula (1). The resulting deuterated vinylpyridine compounds are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 25 00:00:00 EST 2014},
month = {Tue Feb 25 00:00:00 EST 2014}
}
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