Producing dicarboxylic acids using polyketide synthases
Abstract
The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1107783
- Patent Number(s):
- 8569023
- Application Number:
- 12/922,204
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Katz, Leonard, Fortman, Jeffrey L, and Keasling, Jay D. Producing dicarboxylic acids using polyketide synthases. United States: N. p., 2013.
Web.
Katz, Leonard, Fortman, Jeffrey L, & Keasling, Jay D. Producing dicarboxylic acids using polyketide synthases. United States.
Katz, Leonard, Fortman, Jeffrey L, and Keasling, Jay D. Tue .
"Producing dicarboxylic acids using polyketide synthases". United States. https://www.osti.gov/servlets/purl/1107783.
@article{osti_1107783,
title = {Producing dicarboxylic acids using polyketide synthases},
author = {Katz, Leonard and Fortman, Jeffrey L and Keasling, Jay D},
abstractNote = {The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 29 00:00:00 EDT 2013},
month = {Tue Oct 29 00:00:00 EDT 2013}
}
Works referenced in this record:
Recombinant production of novel polyketides
patent, November 1998
- Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Suzanne
- US Patent Document 5,830,750
Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
journal, February 2001
- Heathcote, Michelle L.; Staunton, James; Leadlay, Peter F.
- Chemistry & Biology, Vol. 8, Issue 2, p. 207-220
Recombinant production of novel polyketides
patent, September 1997
- Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Suzanne
- US Patent Document 5,672,491
Recombinant combinatorial genetic library for the production of novel polyketides
patent, January 1998
- Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Suzanne
- US Patent Document 5,712,146
Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase
journal, July 1997
- Jacobsen, J. R.
- Science, Vol. 277, Issue 5324
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway
journal, June 2007
- Erb, T. J.; Berg, I. A.; Brecht, V.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 25, p. 10631-10636
Recombinant production of novel polyketides
patent, December 1998
- Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Susanne
- US Patent Document 5,843,718
A chain initiation factor common to both modular and aromatic polyketide synthases
journal, September 1999
- Bisang, Christian; Long, Paul F.; Corte´s, Jesús
- Nature, Vol. 401, Issue 6752
Polyketides and their synthesis
patent, April 2007
- Leadlay, Peter Francis; Staunton, James; Cortes, Jesus
- US Patent Document 7,198,922
Recombinant methods and materials for producing epothilones C and D
patent, October 2001
- Julien, Bryan; Katz, Leonard; Khosla, Chaitan
- US Patent Document 6,303,342