Recombinant microorganisms for increased production of organic acids
Abstract
Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.
- Inventors:
- Issue Date:
- Research Org.:
- Michigan Biotechnology Institute (Lansing, MI)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1083279
- Patent Number(s):
- 8431373
- Application Number:
- 13/328,894
- Assignee:
- Michigan Biotechnology Institute (Lansing, MI)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- FC36-02GO12001
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Yi, Jian, Kleff, Susanne, and Guettler, Michael V. Recombinant microorganisms for increased production of organic acids. United States: N. p., 2013.
Web.
Yi, Jian, Kleff, Susanne, & Guettler, Michael V. Recombinant microorganisms for increased production of organic acids. United States.
Yi, Jian, Kleff, Susanne, and Guettler, Michael V. Tue .
"Recombinant microorganisms for increased production of organic acids". United States. https://www.osti.gov/servlets/purl/1083279.
@article{osti_1083279,
title = {Recombinant microorganisms for increased production of organic acids},
author = {Yi, Jian and Kleff, Susanne and Guettler, Michael V},
abstractNote = {Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 30 00:00:00 EDT 2013},
month = {Tue Apr 30 00:00:00 EDT 2013}
}
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