Study of polymer molecules and conformations with a nanopore
Abstract
The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1083056
- Patent Number(s):
- 8394640
- Application Number:
- 12/961,021
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- FG02-01ER45922
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 Dec 06
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Golovchenko, Jene A., Li, Jiali, Stein, Derek, and Gershow, Marc H. Study of polymer molecules and conformations with a nanopore. United States: N. p., 2013.
Web.
Golovchenko, Jene A., Li, Jiali, Stein, Derek, & Gershow, Marc H. Study of polymer molecules and conformations with a nanopore. United States.
Golovchenko, Jene A., Li, Jiali, Stein, Derek, and Gershow, Marc H. Tue .
"Study of polymer molecules and conformations with a nanopore". United States. https://www.osti.gov/servlets/purl/1083056.
@article{osti_1083056,
title = {Study of polymer molecules and conformations with a nanopore},
author = {Golovchenko, Jene A. and Li, Jiali and Stein, Derek and Gershow, Marc H.},
abstractNote = {The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 12 00:00:00 EDT 2013},
month = {Tue Mar 12 00:00:00 EDT 2013}
}
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