Imaging mass spectrometer with mass tags
Abstract
A method of analyzing biological material by exposing the biological material to a recognition element, that is coupled to a mass tag element, directing an ion beam of a mass spectrometer to the biological material, interrogating at least one region of interest area from the biological material and producing data, and distributing the data in plots.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1082659
- Patent Number(s):
- 8362415
- Application Number:
- 12/788,146
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA) ; Lawrence Berkeley National Laboratory (Berkeley, CA)
- Patent Classifications (CPCs):
-
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 May 26
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Felton, James S., Wu, Kuang Jen J., Knize, Mark G., Kulp, Kristen S., and Gray, Joe W. Imaging mass spectrometer with mass tags. United States: N. p., 2013.
Web.
Felton, James S., Wu, Kuang Jen J., Knize, Mark G., Kulp, Kristen S., & Gray, Joe W. Imaging mass spectrometer with mass tags. United States.
Felton, James S., Wu, Kuang Jen J., Knize, Mark G., Kulp, Kristen S., and Gray, Joe W. Tue .
"Imaging mass spectrometer with mass tags". United States. https://www.osti.gov/servlets/purl/1082659.
@article{osti_1082659,
title = {Imaging mass spectrometer with mass tags},
author = {Felton, James S. and Wu, Kuang Jen J. and Knize, Mark G. and Kulp, Kristen S. and Gray, Joe W.},
abstractNote = {A method of analyzing biological material by exposing the biological material to a recognition element, that is coupled to a mass tag element, directing an ion beam of a mass spectrometer to the biological material, interrogating at least one region of interest area from the biological material and producing data, and distributing the data in plots.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 29 00:00:00 EST 2013},
month = {Tue Jan 29 00:00:00 EST 2013}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Methods for drug discovery, disease treatment, and diagnosis using metabolomics
patent-application, January 2005
- Kaddurah-Daouk, Rima; Kristal, Bruce
- US Patent Application 10/695265; 20050014132
Imaging mass spectrometer with mass tags
patent, June 2010
- Felton, James S.; Wu, Kuang Jen J.; Knize, Mark G.
- US Patent Document 7,728,287
Single-cell MALDI: a new tool for direct peptide profiling
journal, April 2000
- Li, Lingjun; Garden, Rebecca W.; Sweedler, Jonathan V.
- Trends in Biotechnology, Vol. 18, Issue 4, p. 151-160
Methods for isolation and labeling of sample molecules
patent-application, November 2002
- Aebersold, Ridolf H.; Zhou, Huilin
- US Patent Application 09/858198; 20020168644
Methods for detecting a plurality of analytes by mass spectrometry
patent-application, October 2002
- Matray, Tracy J.; Hernandez, Vincent S.; Chenna, Ahmed
- US Patent Application 10/008593; 20020150927
Methods and kits useful for the simplification of complex peptide mixtures
patent-application, November 2002
- Baker, Christopher
- US Patent Application 10/115301; 20020168691
Use of Mass Labeled Probes to Detect Target Nucleic Acids Using Mass Spectrometry
patent-application, June 2009
- Thompson, Andrew
- US Patent Application 12/356579; 20090156424
Spatial Profiling with MALDI MS: Distribution of Neuropeptides within Single Neurons
journal, September 2003
- Rubakhin, Stanislav S.; Greenough, William T.; Sweedler, Jonathan V.
- Analytical Chemistry, Vol. 75, Issue 20, p. 5374-5380
Method and apparatus for detecting cancerous cells using molecules that change electrophoretic mobility
patent, May 2004
- Allbritton, Nancy; Sims, Christopher
- US Patent Document 6,740,497
Method and device for biochemical detection and analysis of subcellular compartments from a single cell
patent-application, March 2005
- Chiu, Daniel T.; Sun, Bingyun; Shelby, James Patrick
- US Patent Application 10/926656; 20050048581
The contributions of specific amino acid side chains to signal intensities of peptides in matrix-assisted laser desorption/ionization mass spectrometry
journal, April 2004
- Baumgart, Sabine; Lindner, Yvonne; Kühne, Ronald
- Rapid Communications in Mass Spectrometry, Vol. 18, Issue 8
Discovering new neuropeptides using single-cell mass spectrometry
journal, September 2003
- Hummon, Amanda B.; Sweedler, Jonathan V.; Corbin, Rebecca W.
- TrAC Trends in Analytical Chemistry, Vol. 22, Issue 8, p. 515-521
Process for operating a time-of-flight secondary-ion mass spectrometer
patent, May 1997
- Niehuis, Ewald
- US Patent Document 5,633,495
Method for analysis of substances in tissue or in cells
patent-application,
- Yasuda, Akikazu; Yasuda, Yoshimi; Nakajima, Terumi
- US Patent Application 10/220345; 20040137420
Method of analyzing protein occurring in cell or substance interacting with the protein
patent-application, November 2004
- Nakajima, Terumi; Naoki, Hideo; Yasuda, Akikazu
- US Patent Application 10/481011; 20040235062
Method and apparatus for imaging biological samples with MALDI MS
patent, September 1998
- Caprioli, Richard
- US Patent Document 5,808,300
Chemical and Biological Differentiation of Three Human Breast Cancer Cell Types Using Time-of-Flight Secondary Ion Mass Spectrometry
journal, June 2006
- Kulp, Kristen S.; Berman, Elena S. F.; Knize, Mark G.
- Analytical Chemistry, Vol. 78, Issue 11
Method for identifying matched groups
patent-application, November 2004
- Hinds, David; Stokowski, Rene
- US Patent Application 10/427696; 20040220750
Targeted enzymes
patent-application, June 2006
- Chen, Yiyou; Day, Anthony G.; Estell, David A.
- US Patent Application 10/881221; 20060134086
Method and system using acoustic ejection for preparing and analyzing a cellular sample surface
patent, October 2004
- Ellson, Richard N.; Mutz, Mitchell; Caprioli, Richard
- US Patent Document 6,809,315
Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
patent-application, May 2007
- Pevsner, Paul; Naftolin, Frederick; Miller, Douglas C.
- US Patent Application 11/541380; 20070114375
Mass Labels
patent-application, June 2008
- Schmidt, Gunter; Thompson, Andrew Hugin; Johnstone, Robert Alexander Walker
- US Patent Application 11/894735; 20080145850
Methods, devices, and systems using acoustic ejection for depositing fluid droplets on a sample surface for analysis
patent, February 2005
- Ellson, Richard N.; Mutz, Mitchell; Caprioli, Richard
- US Patent Document 6,855,925
Methods and apparatus for analyzing biological samples by mass spectrometry
patent, June 2004
- Caprioli, Richard
- US Patent Document 6,756,586
Works referencing / citing this record:
Protein detection via nanoreporters
patent, July 2017
- Dunaway, Dwayne L.
- US Patent Document 9,714,937