Flow method and apparatus for screening chemicals using micro x-ray fluorescence
Abstract
Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.
- Inventors:
-
- Los Alamos, NM
- Bartlesville, OK
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1016687
- Patent Number(s):
- 7929662
- Application Number:
- US Patent Application 12/396,592
- Assignee:
- Los Alamos National Security, LLC (Los Alamos, NM)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- W-7405-ENG- 36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Warner, Benjamin P, Havrilla, George J, Miller, Thomasin C, Lewis, Cris, Mahan, Cynthia A, and Wells, Cyndi A. Flow method and apparatus for screening chemicals using micro x-ray fluorescence. United States: N. p., 2011.
Web.
Warner, Benjamin P, Havrilla, George J, Miller, Thomasin C, Lewis, Cris, Mahan, Cynthia A, & Wells, Cyndi A. Flow method and apparatus for screening chemicals using micro x-ray fluorescence. United States.
Warner, Benjamin P, Havrilla, George J, Miller, Thomasin C, Lewis, Cris, Mahan, Cynthia A, and Wells, Cyndi A. Tue .
"Flow method and apparatus for screening chemicals using micro x-ray fluorescence". United States. https://www.osti.gov/servlets/purl/1016687.
@article{osti_1016687,
title = {Flow method and apparatus for screening chemicals using micro x-ray fluorescence},
author = {Warner, Benjamin P and Havrilla, George J and Miller, Thomasin C and Lewis, Cris and Mahan, Cynthia A and Wells, Cyndi A},
abstractNote = {Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 26 00:00:00 EDT 2011},
month = {Tue Apr 26 00:00:00 EDT 2011}
}
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