Foldable polymers as probes
Abstract
Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.
- Inventors:
-
- Pullman, WA
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1012639
- Patent Number(s):
- 7556967
- Application Number:
- 11/789,745
- Assignee:
- Washington State University Research Foundation (Pullman, WA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C40 - COMBINATORIAL TECHNOLOGY C40B - COMBINATORIAL CHEMISTRY
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Li, Alexander D. Q., and Wang, Wei. Foldable polymers as probes. United States: N. p., 2009.
Web.
Li, Alexander D. Q., & Wang, Wei. Foldable polymers as probes. United States.
Li, Alexander D. Q., and Wang, Wei. Tue .
"Foldable polymers as probes". United States. https://www.osti.gov/servlets/purl/1012639.
@article{osti_1012639,
title = {Foldable polymers as probes},
author = {Li, Alexander D. Q. and Wang, Wei},
abstractNote = {Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 07 00:00:00 EDT 2009},
month = {Tue Jul 07 00:00:00 EDT 2009}
}
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