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Title: Functionalized apertures for the detection of chemical and biological materials

Abstract

Disclosed are nanometer to micron scale functionalized apertures constructed on a substrate made of glass, carbon, semiconductors or polymeric materials that allow for the real time detection of biological materials or chemical moieties. Many apertures can exist on one substrate allowing for the simultaneous detection of numerous chemical and biological molecules. One embodiment features a macrocyclic ring attached to cross-linkers, wherein the macrocyclic ring has a biological or chemical probe extending through the aperture. Another embodiment achieves functionalization by attaching chemical or biological anchors directly to the walls of the apertures via cross-linkers.

Inventors:
 [1];  [1];  [2];  [2];  [3];  [3]
  1. Livermore, CA
  2. Danville, CA
  3. Brentwood, CA
Issue Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1010280
Patent Number(s):
7851203
Application Number:
10/677,395
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Letant, Sonia E, van Buuren, Anthony W, Terminello, Louis J, Thelen, Michael P, Hope-Weeks, Louisa J, and Hart, Bradley R. Functionalized apertures for the detection of chemical and biological materials. United States: N. p., 2010. Web.
Letant, Sonia E, van Buuren, Anthony W, Terminello, Louis J, Thelen, Michael P, Hope-Weeks, Louisa J, & Hart, Bradley R. Functionalized apertures for the detection of chemical and biological materials. United States.
Letant, Sonia E, van Buuren, Anthony W, Terminello, Louis J, Thelen, Michael P, Hope-Weeks, Louisa J, and Hart, Bradley R. Tue . "Functionalized apertures for the detection of chemical and biological materials". United States. https://www.osti.gov/servlets/purl/1010280.
@article{osti_1010280,
title = {Functionalized apertures for the detection of chemical and biological materials},
author = {Letant, Sonia E and van Buuren, Anthony W and Terminello, Louis J and Thelen, Michael P and Hope-Weeks, Louisa J and Hart, Bradley R},
abstractNote = {Disclosed are nanometer to micron scale functionalized apertures constructed on a substrate made of glass, carbon, semiconductors or polymeric materials that allow for the real time detection of biological materials or chemical moieties. Many apertures can exist on one substrate allowing for the simultaneous detection of numerous chemical and biological molecules. One embodiment features a macrocyclic ring attached to cross-linkers, wherein the macrocyclic ring has a biological or chemical probe extending through the aperture. Another embodiment achieves functionalization by attaching chemical or biological anchors directly to the walls of the apertures via cross-linkers.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 14 00:00:00 EST 2010},
month = {Tue Dec 14 00:00:00 EST 2010}
}

Works referenced in this record:

Highly efficient methods for the preparation of shape-persistent macrocyclics
journal, August 1999


Functionalized silicon membranes for selective bio-organism capture
journal, April 2003