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TitleReport on the Human Genome Initiative for the Office of Health and Environmental Research
Author(s)Tinoco, I.; Cahill, G.; Cantor, C.; Caskey, T.; Dulbecco, R.; Engelhardt, D. L.; Hood, L.; Lerman, L. S.; Mendelsohn, M. L.; Sinsheimer, R. L.; Smith, T.; Soll, D.; Stormo, G.; White, R. L.
Publication DateApril 1987
Unique IdentifierACC0486
Other NumbersOSTI ID: 1057441
Research OrgSubcommittee on Human Genome of the Health and Environmental Research Advisory Committee (HERAC)
Sponsoring OrgU.S. Department of Energy (DOE)
Subject59 Basic Biological Sciences
Related Web PagesHuman Genome: DOE Origins
AbstractThe report urges DOE and the Nation to commit to a large, multi-year, multidisciplinary, technological undertaking to order and sequence the human genome. This effort will first require significant innovation in general capability to manipulate DNA, major new analytical methods for ordering and sequencing, theoretical developments in computer science and mathematical biology, and great expansions in our ability to store and manipulate the information and to interface it with other large and diverse genetic databases. The actual ordering and sequencing involves the coordinated processing of some 3 billion bases from a reference human genome. Science is poised on the rudimentary edge of being able to read and understand human genes. A concerted, broadly based, scientific effort to provide new methods of sufficient power and scale should transform this activity from an inefficient one-gene-at-a-time, single laboratory effort into a coordinated, worldwide, comprehensive reading of "the book of man". The effort will be extraordinary in scope and magnitude, but so will be the benefit to biological understanding, new technology and the diagnosis and treatment of human disease.
15948 K
25 pp.
 
View Document 
  


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