1706 K
33 pp.
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TitleEmission Computed Tomography: A New Technique for the Quantitative Physiologic Study of Brain and Heart in Vivo
Author(s)Phelps, M. E.; Hoffman, E. J.; Huang, S. C.; Schelbert, H. R.; Kuhl, D. E.
Publication Date1978
Report NumberUCLA-12-1176
Unique IdentifierACC0271
Other NumbersOSTI ID: 6290057
Research OrgUniversity of California, Los Angeles (USA). Laboratory of Nuclear Medicine and Radiation Biology
Contract NoEY-76-C-03-0012
Sponsoring OrgUS Energy Research and Development Administration (ERDA)
Subject62 Radiology and Nuclear Medicine; 550601 -- Medicine -- Unsealed Radionuclides in Diagnostics; Blood Flow -- Measuring Methods; Brain -- Tomography; Cardiovascular Diseases -- Diagnostic Techniques; Heart -- Tomography; Labeled Compounds -- Measuring Methods; Radioisotope Scanners -- Design; Tomography; Biological Models; Computers; Image Scanners; Metabolism; Quantitative Chemical Analysis; Radioisotopes; Sensitivity; Spatial Resolution; Tracer Techniques
KeywordsBody; Cardiovascular System; Central Nervous System; Chemical Analysis; Diseases; Isotope Applications; Isotopes; Nervous System; Organs; Resolution
Related Web PagesAllan Cormack, Computerized Axial Tomography [CAT] and Magnetic Resonance Imaging [MRI]
AbstractEmission computed tomography can provide a quantitative in vivo measurement of regional tissue radionuclide tracer concentrations. This facility when combined with physiologic models and radioactively labeled physiologic tracers that behave in a predictable manner allow measurement of a wide variety of physiologic variables. This integrated technique has been referred to as Physiologic Tomography (PT). PT requires labeled compounds which trace physiologic processes in a known and predictable manner, and physiologic models which are appropriately formulated and validated to derive physiologic variables from ECT data. In order to effectively achieve this goal, PT requires an ECT system that is capable of performing truly quantitative or analytical measurements of tissue tracer concentrations and which has been well characterized in terms of spatial resolution, sensitivity and signal to noise ratios in the tomographic image. This paper illustrates the capabilities of emission computed tomography and provides examples of physiologic tomography for the regional measurement of cerebral and myocardial metabolic rate for glucose, regional measurement of cerebral blood volume, gated cardiac blood pools and capillary perfusion in brain and heart. Studies on patients with stroke and myocardial ischemia are also presented.
1706 K
33 pp.
View Document 

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