1547 K
24 pp.
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TitleA Review of Acquired Thermotolerance, Heat Shock Proteins, and Molecular Chaperones in Archaea: Heat Shock in Archaea
Author(s)Trent, J. D.
Publication DateFebruary 09, 1996
Report NumberANL/CMB/CP--89216
Unique IdentifierACC0214
Other NumbersCONF-9606173--1; Legacy ID: DE96010792; OSTI ID: 231978
Research OrgArgonne National Laboratory, IL (United States)
Contract NoW-31109-ENG-38
Sponsoring OrgUSDOE, Washington, DC (United States)
Other Information1996 Federation of European Microbiological Societies (FEMS), Estoril (Portugal), 2-6 Jun 1996
Subject55 Biology And Medicine, Basic Studies; Heat-Shock Proteins; Biosynthesis; Bacteria; Temperature Dependence; Tolerance; Biological Stress
KeywordsHeat Shock
Related Web PagesThe Discovery of Archaea, the 'Third Branch of Life', and Its Impacts
AbstractAcquired thermotolerance, the associated synthesis of heat-shock proteins (HSPs) under stress conditions, and the role of HSPs as molecular chaperones under normal growth conditions have been studied extensively in eukaryotes and bacteria, whereas research in these areas in archaea is only beginning. All organisms have evolved a variety of strategies for coping with high-temperature stress, and among these strategies is the increased synthesis of HSPs. The facts that both high temperatures and chemical stresses induce the HSPs and that some of the HSPs recognize and bind to unfolded proteins in vitro have led to the theory that the function of HSPs is to prevent protein aggregation in vivo. The facts that some HSPs are abundant under normal growth conditions and that they assist in protein folding in vitro have led to the theory that they assist protein folding in vivo; in this role, they are referred to as molecular chaperones. The limited research on acquired thermotolerance, HSPs, and molecular chaperones in archaea, particularly the hyperthermophilic archaea, suggests that these extremophiles provide a new perspective in these areas of research, both because they are members of a separate phylogenetic domain and because they have evolved to live under extreme conditions.
1547 K
24 pp.
View Document 

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