The relative physiological and toxicological properties of americium and plutonium
- and others
The relative physiological and toxicological properties of americium and plutonium have been studied following their intravenous administration to rats. The urinary and fecal excretion of americium was similar to that of plutonium administered as Pu(N0{sub 3}){sub 4}. The deposition of americium the tissues and organs of the rat was also similar to that observed for plutonium. The liver and the skeleton were the major sites of deposition. Zirconium citrate administered 15 minutes after injection of americium increased the urinary excretion of americium and decreased the amount found in the liver and the skeleton at 4 and 16 days. LD{sub 30}{sup 50} studies showed americium was slightly less toxic when given in the acute toxic range than was plutonium. The difference was, however, too slight to be important in establishing a larger tolerance does for americium. Survival studies, hematological observations, bone marrow observations, comparison of tumor incidence and the incidence of skeletal abnormalities indicated that americium and plutonium have essentially the same chronic toxicity when given on an equal {mu}c. basis. These studies support the conclusion that the tolerance values for americium should be essentially the same as those for Plutonium.
- Research Organization:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- OSTI ID:
- 174682
- Report Number(s):
- LA-1309; ON: DE95013620
- Resource Relation:
- Other Information: PBD: 15 Nov 1951
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
APPLIED STUDIES
AMERICIUM
TISSUE DISTRIBUTION
EXCRETION
BIOLOGICAL RADIATION EFFECTS
PLUTONIUM
ZIRCONIUM COMPOUNDS
RADIOSENSITIVITY EFFECTS
RATS
LETHAL DOSES
BONE MARROW
SKELETON
INTRAVENOUS INJECTION
URINE
CHELATING AGENTS
CHLORIDES
NITRATES
CITRATES
ACUTE EXPOSURE
BLOOD
GASTROINTESTINAL TRACT
HEART
KIDNEYS
LIVER
LUNGS
SPLEEN
TESTES
SKIN
FECES
AUTORADIOGRAPHY