Surfactant-assisted synthesis of water-soluble and biocompatible semiconductor quantum dot-micelles.

Journal Article · Fri Apr 01 00:00:00 EST 2005 · Proposed for publication in NanoLetters.

OSTI ID:990080

Brinker, C Jeffrey; Bunge, Scott D; Gabaldon, John ^[1]; Fan, Hongyou; Scullin, Chessa ^[1]; Leve, Erik W ^[1]; Wilson, Michael C ^[1]; Tallant, David Robert; Boyle, Timothy J

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1. University of New Mexico, Albquerque, NM

We report a simple, rapid approach to synthesize water-soluble and biocompatible fluorescent quantum dot (QD) micelles by encapsulation of monodisperse, hydrophobic QDs within surfactant/lipid micelles. Analyses of UV-vis and photo luminescence spectra, along with transmission electron microscopy, indicate that the water-soluble semiconductor QD micelles are monodisperse and retain the optical properties of the original hydrophobic QDs. The QD micelles were shown to be biocompatible and exhibited little or no aggregation when taken up by cultured rat hippocampal neurons.

• Research Organization: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC04-94AL85000
• OSTI ID: 990080
• Report Number(s): SAND2005-2148J; TRN: US201020%%59
• Journal Information: Proposed for publication in NanoLetters., Vol. 5, Issue 4
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
ENCAPSULATION
NERVE CELLS
COMPATIBILITY
OPTICAL PROPERTIES
QUANTUM DOTS
SPECTRA
SYNTHESIS
MICELLAR SYSTEMS
SURFACTANTS
LIPIDS
SEMICONDUCTOR MATERIALS