High-Relaxivity MRI Contrast Agents: Where Coordination Chemistry Meets Medical Imaging
Journal Article
·
· Angewandte Chemie International Edition
The desire to improve and expand the scope of clinical magnetic resonance imaging (MRI) has prompted the search for contrast agents of higher efficiency. The development of better agents requires consideration of the fundamental coordination chemistry of the gadolinium(III) ion and the parameters that affect its efficacy as a proton relaxation agent. In optimizing each parameter, other practical issues such as solubility and in vivo toxicity must also be addressed, making the attainment of safe, high-relaxivity agents a challenging goal. Here we present recent advances in the field, with an emphasis on the hydroxypyridinone family of Gd{sup III} chelates.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- Chemical Sciences Division
- DOE Contract Number:
- DE-AC02-05CH11231; HL69832
- OSTI ID:
- 942144
- Report Number(s):
- LBNL-1192E; TRN: US0807528
- Journal Information:
- Angewandte Chemie International Edition, Vol. 47; Related Information: Journal Publication Date: 2008
- Country of Publication:
- United States
- Language:
- English
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