Balanced nonacrocentric whole-arm reciprocal translocations: A de novo case and literature review

Journal Article · Mon Feb 13 00:00:00 EST 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320550408· OSTI ID:90829

Farrell, S A; Fan, Y S ^[1]

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1. Credit Valley Hospital, Ontario (Canada)

We report a new de novo case of a balanced whole-arm reciprocal translocation, detected at prenatal diagnosis for late maternal age. A review of previous cases indicates there is a risk of chromosomally abnormal liveborn offspring when a parent is a carrier of this type of translocation, particularly when the translocated region is a small chromosomal segment. Due to the limited number of cases, exact reproductive risks are not available. This is the second example of such a translocation of chromosomes 1 and 5, raising the possibility of nonrandom involvement of certain chromosomes in balanced nonacrocentric whole-arm reciprocal translocations. 18 refs., 1 fig., 1 tab.

• OSTI ID: 90829
• Journal Information: American Journal of Medical Genetics, Vol. 55, Issue 4; Other Information: PBD: 13 Feb 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOMES
CHROMOSOMAL ABERRATIONS
GENES
HUMAN CHROMOSOME 1
HUMAN CHROMOSOME 5
FETUSES