Opto-acoustic recanilization delivery system

Patent · Tue Jan 01 00:00:00 EST 2002

OSTI ID:874331

Visuri, Steven R ^[1]; Da Silva, Luiz B ^[2]; Celliers, Peter M ^[3]; London, Richard A ^[4]; Benett, William ^[1]; Broughton, Kathryn ^[3]; Esch, Victor ^[5]

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1. Livermore, CA
2. Danville, CA
3. Berkeley, CA
4. Orinda, CA
5. San Francisco, CA

Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: The Regents of the University of California (Oakland, CA)
• Patent Number(s): US 6368318
• OSTI ID: 874331
• Country of Publication: United States
• Language: English

Related Subjects

opto-acoustic
recanilization
delivery
fiber
delivered
laser
pulses
emulsify
thrombus
mechanical
stresses
combination
pressure
tension
shear
stress
radiation
locality
absorbed
blood
dot
materials
leading
wave
subsequent
vapor
bubble
efficient
emulsification
operating
average
power
mode
alleviates
potential
thermal
complications
operated
repetition
rate
advantage
ultrasound
frequency
effects
dissolution
decrease
total
procedure
time
specific
parameter
ranges
operation
described
device
optical
fibers
surrounding
lumen
intended
flow
cooling
agent
arranged
concentrically
deliver
heat
alternative
design
approach
incorporates
wall
guiding
catheter
utilizes
channel
eccentric
tip
enables
rotation
address
vasculature
eccentricity
provided
via
variety
means
spring
dip
balloon
protrusion
etc
optical fiber
laser pulse
laser radiation
repetition rate
pressure wave
mechanical stress
mechanical stresses
shear stress
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