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Title: Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

Patent ·
OSTI ID:869181
 [1];  [2];  [3]
  1. Coram, NY
  2. Stony Brook, NY
  3. Setauket, NY
+ Show Author Affiliations

Cyclo agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N,N,N',N'-tetra acetic acid.

Research Organization:
Associated Universities, Inc., Upton, NY (United States)
DOE Contract Number:
AC02-76CH00016
Assignee:
Associated Universities, Inc. (Washington, DC)
Patent Number(s):
US 5292938
OSTI ID:
869181
Country of Publication:
United States
Language:
English

References (1)

Stereocontrolled syntheses for the six diastereomeric 1,2-dihydroxy-4,5-diaminocyclohexanes: PtII complexes and P-388 antitumor properties journal August 1987

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Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
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Related Subjects

synthesis
4-substituted-trans-1
2-diaminocyclohexyl
polyaminocarboxylate
metal
chelating
agents
preparation
stable
radiometal
antibody
immunoconjugates
therapy
spect
pet
imaging
cyclo
useful
forming
antibody-metal
conjugates
diagnostic
therapeutic
purposes
compounds
processes
disclosed
including
4-haloacetamido-trans-1
4-isothiocyanato-trans-1
2-diamino
cyclohexane-n
-tetra
acetic
acid
therapeutic purposes
metal chelating
stable radiometal
radiometal antibody
acetic acid
chelating agents
chelating agent
disclosed including
pet imaging
antibody immunoconjugates
agents useful
cyclohexyl polyaminocarboxylate
forming antibody-metal
polyaminocarboxylate metal
/999/530/