Dose rate studies with fission spectrum neutrons
Fission spectrum neutrons produced by the JANUS reactor were used to test the hypothesis that no effect of dose rate or exposure time occurs when mouse lethality or hematopoietic injury is evaluated. Reduction of the dose rate from 13.1 to 1.2 rad/min resulted in a small increase in LD/sub 50///sub 30/ and LD/sub 50///sub 7/. Whereas no dose rate effect was found for cell killing (D/sub 0/) of hematopoietic stem cells in the femur or spleen, mice that received a sublethal dose of 1.2 rad/min showed a small but reproducible advantage in repopulation of stem cells in the femur, and in reappearance of platelets in peripheral circulation. During a course of fractionated neutron irradiation, the femur stem cell content was higher in groups which were irradiated at 0.13 rad/min in comparison with others irradiated at 2.13 rad/min. Thus, the effects of fission spectrum neutrons are not totally independent of dose rate or exposure time based on the end points evaluated in these experiments. The effect of neutron dose rate on cell killing and on division delay or repopulation could vary independently.
- Research Organization:
- Argonne National Lab., IL
- OSTI ID:
- 7356494
- Journal Information:
- Radiat. Res.; (United States), Vol. 67:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CELL KILLING
BIOLOGICAL RADIATION EFFECTS
DOSE RATES
RADIOSENSITIVITY EFFECTS
STEM CELLS
FEMUR
FISSION NEUTRONS
HEMATOPOIETIC SYSTEM
IRRADIATION
MICE
SPLEEN
SURVIVAL TIME
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BODY
ELEMENTARY PARTICLES
FERMIONS
HADRONS
MAMMALS
NEUTRONS
NUCLEONS
ORGANS
RADIATION EFFECTS
RODENTS
SKELETON
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals