Metal isotopes used as radioactive indicators of ocular melanoma

Journal Article · Sat Jan 01 00:00:00 EST 1977 · Am. J. Ophthalmol.; (United States)

DOI:https://doi.org/10.1016/0002-9394(77)90195-7· OSTI ID:7291149

Packer, S; Lambrecht, R M; Christman, D R; Ansari, A N; Wolf, A P; Atkins, H L

We studied radioactive metal compounds to determine their localization in malignant Greene melanoma in the eye of the Syrian golden hamsters. Scintigraphy of an ocular melanoma was achieved with several radioactive metals: radioactive (/sup 111/In)-bleomycin, radioactive gallium (/sup 67/Ga)-citrate, and radioactive lead (/sup 203/Pb)-tris. The /sup 111/In-bleomycin had the highest tumor uptake (5.45% dose/g), but not the highest tumor-to-background ratios. The /sup 67/Ga-citrate had a maximum tumor uptake of 4.87% dose/g at 48 hours. The /sup 111/In-chloride had a melanoma uptake of 2.26% dose/g, while with /sup 203/Pb-tris the uptake was 1.61% dose/g. These uptake ratios compare favorably with that of radioactive phosphorus (/sup 32/P) - 2.21% dose/g. Noninvasive localization of malignant melanoma in the eye was accomplished with metal isotopes. Detailed analysis of in vitro uptake data by tumor and background tissues revealed the optimum time for scanning and precluded unnecessary trials.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 7291149
• Journal Information: Am. J. Ophthalmol.; (United States), Vol. 83:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
EYES
SCINTISCANNING
GALLIUM 67
INDIUM 111
LEAD 203
MELANOMAS
DIAGNOSIS
BLEOMYCIN
CITRATES
HAMSTERS
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID SALTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GALLIUM ISOTOPES
HEAVY NUCLEI
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEAD ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
SENSE ORGANS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics