Sudden hemorrhage in metastatic thyroid carcinoma of the brain during treatment with /sup 131/I

Journal Article · Thu Apr 01 00:00:00 EST 1976 · J. Nucl. Med.; (United States)

OSTI ID:7282493

Holmquest, D L; Lake, P

A patient with papillary--follicular carcinoma of the thyroid, with metastases to the lungs, skeleton, and brain, was treated 5 weeks after thyroidectomy with 135 mCi of /sup 131/I. Although preliminary studies with 1 mCi had not shown any iodine uptake by the brain metastasis, this lesion showed intense concentration at the time of the larger therapeutic dose. Four days later, acute hemorrhage of the tumor occurred, requiring surgical removal. Although /sup 131/I therapy would seem an unlikely cause of acute necrosis and hemorrhage in these lesions, the association of therapeutic radioiodine and hemorrhage is interesting. Since recent reports suggest that brain metastasis may be somewhat more common than previously suspected, we suggest that brain imaging be included in the workup prior to radioiodine therapy of patients with advanced metastatic disease or neurologic symptoms. (auth)

• Research Organization: Texas A and M Univ., College Station
• OSTI ID: 7282493
• Journal Information: J. Nucl. Med.; (United States), Vol. 17:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BRAIN
BIOLOGICAL RADIATION EFFECTS
HEMORRHAGE
RADIOINDUCTION
RADIOTHERAPY
SIDE EFFECTS
CARCINOMAS
IODINE 131
METASTASES
PATIENTS
THYROID
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
SYMPTOMS
THERAPY
560151* - Radiation Effects on Animals- Man