beta. amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome
Journal Article
·
· Science (Washington, D.C.); (United States)
With the recently cloned complementary DNA probe, lambdaAm4 for the chromosome 21 gene encoding brain amyloid polypeptide (..beta.. amyloid protein) of Alzheimer's disease, leukocyte DNA from three patients with sporadic Alzheimer's disease and two patients with karyotypically normal Down syndrome was found to contain three copies of this bene. Because a small region of chromosome 21 containing the ets-2 gene is duplicated in patients with Alzheimer's disease, as well as in karyotypically normal Down syndrome, duplication of a subsection of the critical segment of chromosome 21 that is duplicated in Down syndrome may be the genetic defect in Alzeimer's disease.
- Research Organization:
- CNRS, Paris (France)
- OSTI ID:
- 7252728
- Journal Information:
- Science (Washington, D.C.); (United States), Vol. 235
- Country of Publication:
- United States
- Language:
- English
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