Localized sup 31 P magnetic resonance spectroscopy of large pediatric brain tumors
- Children's Hospital of Philadelphia, PA (USA)
Fourteen children aged 1 week to 16 years, with a variety of large or superficial brain tumors, underwent localized in vivo {sup 31}P magnetic resonance spectroscopy of their tumor. Quantitative spectral analysis was performed by measuring the area under individual peaks using a computer algorithm. In eight patients with histologically benign tumors the spectra were considered to be qualitatively indistinguishable from normal brain. The phosphocreatine/inorganic phosphate ratio (PCr/Pi) averaged 2.0. Five patients had histologically malignant tumors; qualitatively, four of these were considered to have abnormal spectra, showing a decrease in the PCr peak. The PCr/Pi ratio for this group averaged 0.85, which was significantly lower than that seen in the benign tumor group (p less than 0.05). No difference between the two groups was seen in adenosine triphosphate or phosphomonoesters. It is concluded that a specific metabolic fingerprint for childhood brain tumors may not exist, but that some malignant tumors show a pattern suggestive of ischemia.
- OSTI ID:
- 7244449
- Journal Information:
- Journal of Neurosurgery; (USA), Vol. 72:1; ISSN 0022-3085
- Country of Publication:
- United States
- Language:
- English
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BRAIN
NEOPLASMS
PHOSPHATES
METABOLISM
PHOSPHOCREATINE
ADOLESCENTS
ALGORITHMS
ATP
CHILDREN
INFANTS
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
PATIENTS
PHOSPHORUS 31
QUANTITY RATIO
TRACER TECHNIQUES
AGE GROUPS
AMINO ACIDS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
DISEASES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MATHEMATICAL LOGIC
NERVOUS SYSTEM
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PHOSPHORUS ISOTOPES
RESONANCE
SPECTRA
STABLE ISOTOPES
550901* - Pathology- Tracer Techniques