Evaluation of ultrastructural hepatic response to environmental toxicants in wild cotton rats (Sigmodon hispidus)

Journal Article · Thu Aug 01 00:00:00 EDT 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01688659· OSTI ID:7235830

Elangbam, C S; Qualls, C W; Confer, A W ^[1]

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1. Oklahoma State Univ., Stillwater (United States)

Hepatic lobules are composed of hepatocytes organized in three microcirculatory zones (periportal, midzonal, and centrilobular). The hepatocytes in each of these zones contain enzymes which are involved in various biochemical reactions. The predominant location of the mixed-function oxidation system in the liver lobule is the centrilobular zone. Ultrastructural changes in the hepatocytes not only correlate with biochemical events of detoxification but also with toxic effects of a parent compound or its metabolites. The objectives of this study was to characterize the ultrastructural alterations in the liver of wild cotton rats (Sigmodon hispidus) following exposure to polychlorinated biphenyls (PCB) contaminated habitat.

• OSTI ID: 7235830
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 47:2; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINATED AROMATIC HYDROCARBONS
BIOLOGICAL EFFECTS
LIVER CELLS
ULTRASTRUCTURAL CHANGES
MIXED-FUNCTION OXIDASES
BIOCHEMISTRY
RATS
ANIMAL CELLS
ANIMALS
AROMATICS
CHEMISTRY
ENZYMES
HALOGENATED AROMATIC HYDROCARBONS
MAMMALS
MORPHOLOGICAL CHANGES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXIDOREDUCTASES
OXYGENASES
PROTEINS
RODENTS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology