Effects of local irradiation on the excretion of sodium and water by the canine kidney. [X Radiation]
Clearance studies were performed in 16 dogs with surgically formed hemibladders after the left kidney had received a single dose of 2000 rad of x-irradiation. The dogs were studied under conditions of water and osmotic diuresis 1 day and at weekly intervals postexposure, for a period of 2 to 8 weeks. In water diuresis, urine flow (V) was significantly greater from the irradiated kidney (IK) than from the control kidney (CK). These differences became greater over the interval of the study and were independent of changes in glomerular filtration rate (GFR), but were positively correlated with differences in free water clearance (C/sub H/sub 2/O/), indicating that the reabsorption of sodium in the proximal tubule was suppressed. When vasopressin was infused, no differences in the ability to reabsorb C/sub H/sub 2/O/ were evident until 28 days after exposure. At this time, negative free water clearance (T/sup c//sub H/sub 2/O/) was significantly reduced, averaging 0.30 +- 0.08 ml/min (SE) and 0.52 +- 0.08 ml/min from the IK and CK, respectively (P less than 0.01). This defect was also seen when the tubular maximum for T/sup c//sub H/sub 2/O/(Tm/sup c//sub H/sub 2/O/) was determined (1.18 +- 0.1 ml/min from CK and 0.015 +- 0.13 ml/min from IK, P less than 0.001) and when urine osmolality was determined 18-24 hr after complete food and water deprivation (930 +- 148 and 1898 +- 259 mosmol/liter for IK and CK, respectively, P less than 0.05). These studies suggest that renal tubular injury is the major early effect of radiation on renal function, with the earliest effects seen in the proximal tubule followed by marked impairment of the concentrating segment.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD
- OSTI ID:
- 7187430
- Journal Information:
- Radiat. Res.; (United States), Vol. 66:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
KIDNEYS
RADIATION INJURIES
SODIUM
EXCRETION
VASOPRESSIN
BIOLOGICAL EFFECTS
WATER
DOGS
RENAL CLEARANCE
URINE
X RADIATION
ALKALI METALS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CLEARANCE
ELECTROMAGNETIC RADIATION
ELEMENTS
HORMONES
HYDROGEN COMPOUNDS
INJURIES
IONIZING RADIATIONS
MAMMALS
METALS
ORGANS
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIATIONS
VERTEBRATES
WASTES
560152* - Radiation Effects on Animals- Animals