Age-dependent changes in expression of alpha/sub 1/-adrenergic receptors in rat myocardium
The expression of alpha/sub 1/-adrenergic receptors within ventricular myocardium of rats ranging in age from 21 days of fetal life to 24 months after birth was measured from (/sup 125/I) 2-(..beta.. hydroxy phenyl) ethylaminomethyl tetralone binding isotherms. No difference was observed in binding affinity between any of the age groups studied. The number of alpha/sub 1/-adrenergic receptors was found to be 60-120% higher in membranes from fetal or immature rats up to 25 days of age when compared with adult animals. The increased expression of alpha/sub 1/-adrenergic receptors in the developing heart relative to that observed in adult heart is consistent with the hypothesis that alpha/sub 1/-adrenergic receptor stimulation may modulate protein synthesis and growth in mammalian myocardium.
- Research Organization:
- Duke Univ. Medical Center, Durham, NC
- OSTI ID:
- 7171532
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Vol. 138:1
- Country of Publication:
- United States
- Language:
- English
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MYOCARDIUM
RECEPTORS
BIOCHEMICAL REACTION KINETICS
AGE DEPENDENCE
EXPERIMENTAL DATA
IODINE 125
LABELLED COMPOUNDS
RATS
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
DATA
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
HEART
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MEMBRANE PROTEINS
MUSCLES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques