The effects of magnetic resonance imaging and x-irradiation on eye development in the C57B1 mouse
This investigation was undertaken in order to ascertain the effects of magnetic resonance imaging (MRI) radiation fields and x-irradiation, alone and in combination, on the developing eye of the mouse strain C57B16J. Dams in groups of 15 were subjected to absorbed doses of 5, 15, and 30 cGy. Other Dams (N = 15) were exposed to MRI fields under clinically realistic conditions with and without prior x-irradiation. The developing eye was the biological end point. It was found that the 30 cGy dose resulted in teratogenic significance for the C57B1 mouse. MRI fields were found to produce malformation rates higher than control animals. Groups exposed to both types of radiation fields demonstrated malformation levels similar to the 30 cGy irradiated animals with no additive effect detected. The malformation rates and degree of statistical significance varied somewhat with unit of measurement, statistical test, and analytical method. The results confirmed low level x-ray teratogenicity and suggested for the first time the potential of MRI to produce development malformations in an animal model.
- Research Organization:
- North Carolina Univ., Chapel Hill, NC (USA). Inst. of Statistics
- OSTI ID:
- 7150577
- Resource Relation:
- Other Information: Thesis (Ph.D)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
EYES
RADIOSENSITIVITY
NMR IMAGING
BIOLOGICAL EFFECTS
NUCLEAR MAGNETIC RESONANCE
TERATOGENESIS
X RADIATION
BIOLOGICAL RADIATION EFFECTS
EXPERIMENTAL DATA
LOCAL IRRADIATION
MICE
TERATOGENS
ANIMALS
BODY
BODY AREAS
DATA
DIAGNOSTIC TECHNIQUES
ELECTROMAGNETIC RADIATION
FACE
HEAD
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAGNETIC RESONANCE
MAMMALS
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RADIATIONS
RESONANCE
RODENTS
SENSE ORGANS
VERTEBRATES
560151* - Radiation Effects on Animals- Man