Immunogenetic analysis of cellular interactions governing the recruitment of T lymphocytes and monocytes in lymphocytic choriomeningitis virus-induced immunopathology
The Lyt2+ class I major histocompatibility complex (MHC)-restricted virus-immune T cells that induce murine lymphocytic choriomeningitis (LCM) are targeted onto radiation-resistant cells in the central nervous system of virus-infected mice. The use of appropriate bone marrow radiation chimeras as LCM virus-infected, (immunosuppressed recipients for immune T-cell transfer has established that, though bone marrow-derived cells can stimulate virus-specific cytotoxic T lymphocytes (CTL) in spleen, they do not reconstitute the barrier to T-cell recruitment from blood to cerebrospinal fluid. This is true for chimeras made up to 8 months previously, even though the inflammatory monocytes and macrophages in such chimeras are all of donor bone marrow origin. Radiation-resistant cells in the spleens of these chimeras are also still able to further stimulate virus-immune CTL. There is no requirement for H-2 compatibility between virus-immune T lymphocytes and secondarily recruited monocytes, or T cells of an inappropriate specificity. The key event in LCM immunopathology may thus be localization of T cells to the antigen-presenting endothelium in brain, leading to the secretion of mediators that promote the nonspecific recruitment of monocytes and other T cells.
- Research Organization:
- John Curtin School of Medical Research, Canberra (Australia)
- OSTI ID:
- 7130439
- Journal Information:
- Clin. Immunol. Immunopathol.; (United States), Vol. 47:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IMMUNITY
RADIOINDUCTION
LYMPHOCYTES
BIOLOGICAL LOCALIZATION
CELL DIFFERENTIATION
MONOCYTES
BLOOD
BONE MARROW CELLS
CENTRAL NERVOUS SYSTEM
CEREBROSPINAL FLUID
IMMUNOSUPPRESSION
MICE
RADIATION CHIMERAS
SPLEEN
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD CELLS
BODY
BODY FLUIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
LEUKOCYTES
MAMMALS
MATERIALS
MOSAICISM
NERVOUS SYSTEM
ORGANS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals