The inherent cellular radiosensitivity of epithelial ovarian carcinoma

Journal Article · Fri Dec 01 00:00:00 EST 1989 · Gynecologic Oncology; (USA)

DOI:https://doi.org/10.1016/0090-8258(89)90063-2· OSTI ID:7105071

Rotmensch, J; Schwartz, J L; Atcher, R W; Grdina, D J; Toohill, M; Weichselbaum, R W ^[1]

---

1. Univ. of Chicago, IL (USA)

Ovarian carcinomas of similar histology have variable responses to radiation therapy. It has been suggested that inherent cellular resistance to radiation may in part underlie radiotherapy failure. To determine in vitro radiobiological parameters of papillary serous adenocarcinoma of the ovary, we investigated the cellular responses of 16 early-passage ovarian carcinoma cell lines to radiation. The radiosensitivity, as measured by D0, ranged from 1.05 to 2.40 Gy (mean 1.70 Gy), and, as measured by D, ranged from 1.65 to 3.54 Gy (mean 2.38 Gy). The extrapolation number -n ranged from 1.1 to 2.0 (mean 1.5). The cells had a 1.3- to 5.4-fold (mean 2.8) ability to recover from potential lethal damage (PLDR) 24 hr after irradiation and subculture from plateau-phase cultures. Their inherent radioresistance may be one factor in the failure of some ovarian cancers to be sterilized by radiation.

• OSTI ID: 7105071
• Journal Information: Gynecologic Oncology; (USA), Vol. 35:3; ISSN 0090-8258
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OVARIES
CARCINOMAS
TUMOR CELLS
RADIOSENSITIVITY
EPITHELIUM
MAN
PHENOTYPE
RADIATION DOSES
SURVIVAL TIME
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
DISEASES
DOSES
FEMALE GENITALS
GONADS
MAMMALS
NEOPLASMS
ORGANS
PRIMATES
TISSUES
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture